/SRP:/ Immediate first aid: Remove patient from contact with the material. Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Inorganic Bases/Alkaline Corrosives and Related Compounds/
/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 6 to 12 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool ... . Do not attempt to neutralize. Cover skin burns with dry sterile dressings after decontamination ... . /Inorganic Bases/Alkaline Corrosives and Related Compounds/
/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Early intubation, at the first signs of upper airway obstruction, may be necessary. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Inorganic Bases/Alkaline Corrosives and Related Compounds/
来源:Hazardous Substances Data Bank (HSDB)
毒理性
人类毒性摘录
/替代和体外测试/ 本研究的目的是比较钙铝水泥与几种当前使用的直接修复材料的细胞毒性效果。使用了三种复合材料（QuiXfil、Tetric Ceram、Filtek SuprEMe）、一种锌磷酸水泥（Harvard CEMent）、一种玻璃离子水泥（Ketac Molar）和一种钙铝水泥（DoxaDent）的新鲜样本，或者在37°C、pH 7.2的细胞培养介质中预培养7天后的样本。ISO 10993-5细胞毒性测试使用PVC条作为阳性对照，玻璃样本作为阴性对照。L-929成纤维细胞（人类牙龈成纤维细胞）（5毫升分装，含有3 x 10^4细胞/毫升），在含有10% FCS、1%谷氨酰胺和1%青霉素/链霉素的DMEM中，于37°C/5% CO2下培养并经过胰蛋白酶处理，暴露于样本72小时。收集细胞，离心，并在500 uL DMEM中重新悬浮，然后在488 nm下用流式细胞仪在500 uL DMEM中计数30秒。方差分析比较这六种材料对L-929成纤维细胞毒性的影响显示出不同的影响（p <0.0001）。所有样本的细胞毒性随着预培养时间的增加而降低（p <0.0001）。新鲜的DoxaDent表现出最低的细胞毒性，其次是QuiXfil。Ketac Molar表现出最高的细胞毒性。经过7天的预培养后，Harvard CEMent和Filtek SuprEMe显示出比其他材料更高的细胞毒性（p <0.005）。/钙铝水泥/
/ALTERNATIVE and IN VITRO TESTS/ The objective of this study was to compare the cytotoxic effects of a calcium aluminate cement with several currently used direct restorative materials. Specimens of three composites (QuiXfil, Tetric Ceram, Filtek Supreme), one zinc phosphate cement (Harvard Cement), one glass ionomer cement (Ketac Molar), and one calcium aluminate cement (DoxaDent), were used fresh or after 7-days' preincubation in cell culture medium at 37 degrees C, pH 7.2. PVC strips for ISO 10993-5 cytotoxicity test were used as positive control and glass specimens as negative control. L-929 fibroblasts /human gingival fibroblasts/ (5-mL aliquots, containing 3 x 10+4 cells/mL), cultivated in DMEM with 10% FCS, 1% glutamine, and 1% penicillin/streptomycin at 37 degrees C/5% CO2 and trypsinized, were exposed to the specimens for 72 hr. The cells were harvested, centrifuged, and resuspended in 500 uL DMEM and then counted in 500 uL DMEM for 30 sec with a flow cytometer at 488 nm. The analysis of variance comparing the six materials showed different influences on L-929 fibroblast cytotoxicity (p <0.0001). The cytotoxicity of all specimens diminished with increasing preincubation time (p <0.0001). Fresh DoxaDent exhibited the lowest cytotoxicity, followed by QuiXfil. Ketac Molar showed the highest cytotoxicity. After 7 days of preincubation, Harvard Cement and Filtek Supreme demonstrated more cytotoxicity than the other materials (p <0.005). /Calcium aluminate cement/
Preparation of isophorone and mesityl oxide from acetone
申请人：Union Carbide Corporation
公开号：US04535187A1
公开（公告）日：1985-08-13
The aldol condensation of acetone to isophorone and mesityl oxides in high conversions and efficiencies is achieved by a catalyst comprising a calcined calcium salt deposited on an alumina support.
