氯化铜（64Cu） | 35121-64-3

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属盐
• 中文名称: 氯化铜（64Cu）
• 英文名称: copper chloride
• 英文别名: (64)copper(II) chloride；copper-64 chloride；Cupric chloride anhydrous Cu-64；copper-64(2+);dichloride
• CAS: 35121-64-3
• 化学式: Cl₂Cu
• 分子量: 134.906
• InChiKey: ORTQZVOHEJQUHG-OUMJLSBWSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  1.38
• 重原子数：
  3
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  N,N',N''-tris(6-methyl-2-pyridylmethyl)-1,3,5-cis,cis-triaminocyclohexane 、 氯化铜（64Cu） 在 CH₃COONH₄ 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of novel 1,3,5-cis,cis-triaminocyclohexane ligand based Cu(II) complexes as potential radiopharmaceuticals and correlation of structure and serum stability

  摘要：

  The present study describes the synthesis of Cu(II) and radioactive Cu-67.64(II) complexes with N,N',N"-tris(2-pyridylmethyl)-1,3,5-cis,cis-triaminocyclohexane (tachpyr) and a new pyridyl ring alkylated derivative, N,N',N"-tris(6-methyl-2-pyridylmethyl)1,3,5-cis,cis-triaminocyclohexane (tach-6-Me-pyr) and the investigation of their structural and solution properties as well as stability in human serum. Facile formation of both the `cold' and Cu-67.64-radiolabeled complexes, [Cu(tachpyr)](2+) and [Cu(tach-6-Me-pyr)](2+), occurs in aqueous (0.15 M NH4OAc buffer, pH 6.5) or methanolic solvent. X-ray crystallography reveals that Cu(II) is hexacoordinate in [Cu(tachpyr)](2+) while methylation at the 6-position of the pyridyl donors in tachpyr produces considerable steric hindrance. Thus one pyridyl arm of tach-6-Mepyr is rotated entirely away from copper in [Cu(tach-6-Mepyr)](2+), resulting in a highly distorted trigonal-bipyramidal coordination geometry. The solid-state structures of the complexes correlate well with their stabilities in human serum at 37 degreesC. Thus, [Cu-67(tachpyr)](2+) possesses excellent stability, being unchanged after a period of 7 days, while [Cu-67(tach-6-Mepyr)](2+) decomposes within 1 h. Tachpyr may be an excellent candidate for developing new Cu(II) radiopharmaceuticals for diagnosis and therapy. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0277-5387(01)00927-5

文献信息

• Revival of TE2A; a better chelate for Cu(II) ions than TETA?
  作者：Darpan N. Pandya、Jung Young Kim、Jeong Chan Park、Hochun Lee、Prasad B. Phapale、Wonjung Kwak、Tae Hyun Choi、Gi Jeong Cheon、Young-Ran Yoon、Jeongsoo Yoo

  DOI：10.1039/b925703a

  日期：——

  A highly effective synthetic route for TE2A was developed and the 64Cu-labeled TE2A complexes showed higher kinetic inertness and faster clearance than most commonly used TETA analogs.

  开发了一种高效的TE2A合成路线，标记有64Cu的TE2A复合物表现出比最常用的TETA类似物更高的动力学惰性和更快的清除速度。
• Functionalized Bis(thiosemicarbazonato) Complexes of Zinc and Copper:  Synthetic Platforms Toward Site-Specific Radiopharmaceuticals
  作者：Jason P. Holland、Franklin I. Aigbirhio、Helen M. Betts、Paul D. Bonnitcha、Paul Burke、Martin Christlieb、Grant C. Churchill、Andrew R. Cowley、Jonathan R. Dilworth、Paul S. Donnelly、Jennifer C. Green、Josephine M. Peach、Sridhar R. Vasudevan、John E. Warren

  DOI：10.1021/ic0615628

  日期：2007.1.1

  neutral zinc(II) and copper(II) complexes have been synthesized. These bifunctional ligands both chelate the metal ions and provide pendent amino groups that can be readily functionalized with biologically active molecules. Functionalization has been demonstrated by the synthesis of three water-soluble glucose conjugates of the new zinc(II) bis(thiosemicarbazonato) complexes, and their copper(II) analogues

  合成了两种新型不对称双(氨基硫脲)前配体及其中性锌(II)和铜(II)配合物。这些双功能配体既能螯合金属离子，又能提供易于被生物活性分子官能化的侧氨基。功能化已通过新型锌 (II) 双(氨基硫代氨基) 配合物的三种水溶性葡萄糖缀合物的合成得到证实，并且它们的铜 (II) 类似物已通过金属转移在水溶液中制备。包括 NMR、电子顺磁共振、循环伏安法、高效液相色谱 (HPLC)、UV/vis 和荧光发射光谱在内的一系列技术已用于表征复合物。四种化合物，包括两种锌 (II) 配合物，已通过 X 射线晶体学进行了表征。葡萄糖缀合物的连接性和构象已通过NMR光谱确定。时间相关的密度泛函理论计算已用于指定铜 (II) 双（硫代氨基脲）生色团的电子跃迁。使用放射性 HPLC 制备和表征了两种铜 64 放射性标记的复合物，包括一种葡萄糖缀合物，并且金属转移被证明是用铜放射性核素放射性标记化合物的可行方法。已
• Synthesis and characterization of novel tetrahedral copper(I) complexes comprising tridentate PNP-aminodiphosphines and tetradentate PN(X)P-substituted aminodiphosphines (X=O, S)
  作者：Valentina Peruzzo、Cornelia Pretzsch、Francesco Tisato、Marina Porchia、Fiorenzo Refosco、Cristina Marzano、Valentina Gandin、Eik Schiller、Martin Walther、Hans-Jürgen Pietzsch

  DOI：10.1016/j.ica.2012.01.012

  日期：2012.5

  Two series of novel tetrahedral copper(I) complexes comprising tridentate PNP-aminodiphosphines and tetradentate PN(X) P-substituted aminodiphosphines (X = O, S) have been prepared and characterized by conventional physico-chemical techniques. The first series includes '3 + 1'-type complexes comprising an aromatic PNP-aminodiphosphine and acetonitrile or triphenylphosphine. In the second series, the central amine function of the PNP-ligand was substituted with functionalized pendant arms containing ether, hydroxyl or thioether groups to enhance the chelation ability of the ligand. Fully coordinated neutral and cationic complexes were isolated. A preliminary study investigating both the labeling of Cu-64 with the prototype PN(S)P ligand and the potential cytotoxic activity of the 'cold' [Cu(PN(S)P)][BF4] complex is reported. (C) 2012 Elsevier B. V. All rights reserved.
• Synthesis of novel 1,3,5-cis,cis-triaminocyclohexane ligand based Cu(II) complexes as potential radiopharmaceuticals and correlation of structure and serum stability
  作者：Gyungse Park、Ekaterina Dadachova、Ann Przyborowska、Su-jen Lai、Dangshe Ma、Grant Broker、Robin D. Rogers、Roy P. Planalp、Martin W. Brechbiel

  DOI：10.1016/s0277-5387(01)00927-5

  日期：2001.12

  The present study describes the synthesis of Cu(II) and radioactive Cu-67.64(II) complexes with N,N',N"-tris(2-pyridylmethyl)-1,3,5-cis,cis-triaminocyclohexane (tachpyr) and a new pyridyl ring alkylated derivative, N,N',N"-tris(6-methyl-2-pyridylmethyl)1,3,5-cis,cis-triaminocyclohexane (tach-6-Me-pyr) and the investigation of their structural and solution properties as well as stability in human serum. Facile formation of both the `cold' and Cu-67.64-radiolabeled complexes, [Cu(tachpyr)](2+) and [Cu(tach-6-Me-pyr)](2+), occurs in aqueous (0.15 M NH4OAc buffer, pH 6.5) or methanolic solvent. X-ray crystallography reveals that Cu(II) is hexacoordinate in [Cu(tachpyr)](2+) while methylation at the 6-position of the pyridyl donors in tachpyr produces considerable steric hindrance. Thus one pyridyl arm of tach-6-Mepyr is rotated entirely away from copper in [Cu(tach-6-Mepyr)](2+), resulting in a highly distorted trigonal-bipyramidal coordination geometry. The solid-state structures of the complexes correlate well with their stabilities in human serum at 37 degreesC. Thus, [Cu-67(tachpyr)](2+) possesses excellent stability, being unchanged after a period of 7 days, while [Cu-67(tach-6-Mepyr)](2+) decomposes within 1 h. Tachpyr may be an excellent candidate for developing new Cu(II) radiopharmaceuticals for diagnosis and therapy. (C) 2001 Elsevier Science Ltd. All rights reserved.