氯钌(1+)氯化物氨合物(1:1:5) | 137729-23-8

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属盐
• 中文名称: 氯钌(1+)氯化物氨合物(1:1:5)
• 中文别名: 氯化五氨合氯钌(II)；氯五氨合钌(II)氯化物；2H-吡喃-2-醇,6-(1,1-二甲基乙基)二甲基硅杂氧基甲基四氢-3-甲氧基-5-(苯基甲氧基)-2-(2-丙烯基)-,2S-(2.α.,3.α.,5.α.,6.β.)-
• 英文名称: [RuCl(NH₃)₅]Cl
• 英文别名: [Ru(NH₃)₅Cl]Cl；pentaamminechlororuthenium(II) chloride；Chloropentaammineruthenium(II) chloride；azane;chlororuthenium(1+);chloride
• CAS: 137729-23-8
• 化学式: ClH₁₅N₅Ru*Cl
• 分子量: 257.129
• InChiKey: MEEVMUZSVXLKBU-UHFFFAOYSA-L

物化性质

• 熔点：
  314-315 °C(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  2.19
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  5
• 氢给体数：
  5
• 氢受体数：
  5

安全信息

• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• 危险标志：
  GHS07
• 危险性描述：
  H315,H319,H335
• 危险性防范说明：
  P261,P305 + P351 + P338

SDS

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Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
Product name : Chloropentaammineruthenium(II) chloride
CAS-No. : 137729-23-8

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Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Skin irritation (Category 2)
Eye irritation (Category 2)
Specific target organ toxicity - single exposure (Category 3)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Irritating to eyes, respiratory system and skin.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal word Warning
Hazard statement(s)
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Precautionary statement(s)
Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Supplemental Hazard none
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R36/37/38 Irritating to eyes, respiratory system and skin.
S-phrase(s)
S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S36 Wear suitable protective clothing.
Other hazards - none

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Formula : H15Cl2N5Ru
Molecular Weight : 257,13 g/mol
Component Concentration
Chloropentaammineruthenium(II) chloride
CAS-No. 137729-23-8 -

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Section 4. FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Indication of any immediate medical attention and special treatment needed
no data available

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Section 5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
nitrogen oxides (NOx), Hydrogen chloride gas, Ruthenium oxide
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure
adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
protection.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Light sensitive.
Specific end uses
no data available

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Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested
and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
impervious clothing, The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.
Use respirators and components tested and approved under appropriate government standards
such as NIOSH (US) or CEN (EU).

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) Appearance Form: powder
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing Melting point/range: 314 - 315 °C - lit.
point
f) Initial boiling point and no data available
boiling range
g) Flash point not applicable
h) Evaporation rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density no data available
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Autoignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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Section 10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
Light.
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available

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Section 11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation.
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. Causes respiratory tract irritation.
Ingestion May be harmful if swallowed.
Skin May be harmful if absorbed through skin. Causes skin irritation.
Eyes Causes serious eye irritation.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Additional Information
RTECS: Not available

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Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available

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Section 13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
professional waste disposal service to dispose of this material. Dissolve or mix the material with a
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

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Section 14. TRANSPORT INFORMATION
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

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Section 15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  氯钌(1+)氯化物氨合物(1:1:5) 、 2-(1-(6-acetylpyridin-2-yl)ethylidene)-N-(p-tolyl)hydrazine-1-carbothioamide 在 Et₃N 作用下， 以 乙醇 、 水 为溶剂， 生成
  参考文献：
  名称：

  Maji, Milan; Ghosh, Saktiprosad; Chattopadhyay, Shyamal Kumar, Inorganic Chemistry, 1997, vol. 36, # 14, p. 2938 - 2943

  摘要：

  DOI：

文献信息

• Redox Stability Controls the Cellular Uptake and Activity of Ruthenium‐Based Inhibitors of the Mitochondrial Calcium Uniporter (MCU)
  作者：Joshua J. Woods、James Lovett、Barry Lai、Hugh H. Harris、Justin J. Wilson

  DOI：10.1002/anie.202000247

  日期：2020.4.16

  . The best-known inhibitor of the MCU is the ruthenium compound Ru360. Although this compound is effective in permeabilized cells, it does not work in intact biological systems. We have recently reported the synthesis and characterization of Ru265, a complex that selectively inhibits the MCU in intact cells. Here, the physical and biological properties of Ru265 and Ru360 are described in detail. Using

  线粒体钙单向转运蛋白（MCU）是介导线粒体中Ca2 +吸收的离子通道。MCU抑制剂作为研究线粒体Ca2 +的潜在治疗剂和工具非常有价值。MCU的最著名抑制剂是钌化合物Ru360。尽管该化合物在透化细胞中有效，但在完整的生物系统中不起作用。我们最近报道了Ru265的合成和表征，Ru265是一种选择性抑制完整细胞中MCU的复合物。在此，详细描述Ru265和Ru360的物理和生物学特性。使用原子吸收光谱法和X射线荧光成像，我们显示Ru265被有机阳离子转运蛋白3（OCT3）转运，并且比Ru360更有效地被吸收。为了解释Ru360细胞吸收不良的原因，我们表明Ru360被生物还原剂灭活。这些数据突显了金属络合物中的结构修饰如何对其生物活性产生深远影响。
• A Dinuclear Persulfide‐Bridged Ruthenium Compound is a Hypoxia‐Selective Hydrogen Sulfide (H ₂ S) Donor
  作者：Joshua J. Woods、Justin J. Wilson

  DOI：10.1002/anie.202012620

  日期：2021.1.18

  Hydrogen sulfide (H2S) is a gaseous molecule that has received attention for its role in biological processes and therapeutic potential in diseases, such as ischemic reperfusion injury. Despite its clinical relevance, delivery of H2S to biological systems is hampered by its toxicity at high concentrations. Herein, we report the first metal‐based H2S donor that delivers this gas selectively to hypoxic

  硫化氢 (H 2 S) 是一种气体分子，因其在生物过程中的作用和在疾病（例如缺血性再灌注损伤）中的治疗潜力而受到关注。尽管具有临床相关性，但 H 2 S 向生物系统的输送因其高浓度的毒性而受到阻碍。在此，我们报告了第一个金属基 H 2 S 供体，可选择性地将这种气体输送到缺氧细胞。我们进一步表明，该化合物释放的 H 2 S 可以保护 H9c2 大鼠成肌细胞免受缺血性再灌注损伤的体外模型的影响。这些结果验证了氧化还原激活金属配合物作为缺氧选择性 H 2 S 释放剂的实用性，可用作研究这种气体分子在复杂生物系统中的作用的工具。
• Intramolecular electron transfer in cyanide-bridged ruthenium dimers
  作者：Adrian Ponce、Max Bachrach、Patrick J. Farmer、Jay R. Winkler

  DOI：10.1016/0020-1693(95)04900-2

  日期：1996.2

  transient-absorption spectra of [(bpy)(tpy)Ru II (CN)] + (bpy = 2,2′-bipyridine; tpy = 2,2′:6′2″-terpyridine) and [(bpy)(tpy)Ru II CNRu II,III (NH 3 ) 5 ] 3+,4+ have been measured. Metal-to-ligand charge-transfer (MLCT) excitation of the monomer produces an excited state that decays with a rate constant of 1.3 × 10 8 s −1 . Picosecond excitation of [(bpy)(tpy)Ru II CNRu II (NH 3 ) 5 ] 4+ does not lead to any

  摘要[（bpy）（tpy）Ru II（CN）] +（bpy = 2,2'-联吡啶; tpy = 2,2'：6'2''-三联吡啶的吸收，发光和瞬态吸收光谱和[（bpy）（tpy）Ru II CNRu II，III（NH 3）5] 3 +，4 +已被测量。单体的金属至配体电荷转移（MLCT）激发产生激发态，该激发态以1.3×10 8 s -1的速率常数衰减。[（bpy）（tpy）Ru II CNRu II（NH 3）5] 4+的皮秒激发不会导致任何可检测到的瞬变，表明弛豫速率常数> 10 12 s -1。在[（bpy）（tpy）Ru II CNRu II（NH 3）5] 3+的皮秒激发后，观察到由[（bpy）（tpy .-）Ru II CNRu III（NH 3）5] 3+引起的瞬变。 ; 该中间体通过分子内电子传递以3.8×10 10 s -1的速率常数衰减。
• DNA interaction with dipolar ruthenium(II) ammine complexes containing 4,4′-bipyridinium as photochemotherapeutic agents
  作者：Yasuo Nakabayashi、Hitomi Nakamura、Yuya Kubota、Mika Morimoto、Tomotaka Kawasaki、Misaki Nakai、Osamu Yamauchi

  DOI：10.1016/j.ica.2014.07.071

  日期：2014.11

  DNA with dipolar ruthenium(II) ammine complexes containing 4,4′-bipyridinium cations L+, [Ru(L+)(NH3)5]3+, has been investigated by spectroscopic and electrochemical methods. These ruthenium(II) complexes undergo strong stacking interactions of L+ with the base-pairs of DNA duplex in addition to the electrostatic and hydrogen binding modes. The phbp+ ([2]3+) and pymbp+ ([3]3+) complexes bind to DNA more

  通过光谱和电化学方法研究了DNA与含有4,4'-联吡啶阳离子L +，[Ru（L +）（NH 3）5 ] 3+的偶极钌（II）胺配合物的相互作用。这些钌（II）络合物除了具有静电和氢键结合模式外，还经历了L +与DNA双链体碱基对的强堆积反应。phbp +（[[ 2 ] 3+）和pymbp +（[ 3 ] 3+）复合物与DNA的结合比mebp +（[ 1 ] 3+由于存在扩展的平面型芳香族配体，因此）。[ 3 ]与DNA相互作用最强的3+可以在光诱导的配体pymbp +和NH 3损失后与超螺旋质粒pBR322 DNA结合。该发现导致有氧和无氧条件下可见光对[ 3 ] 3+的超螺旋质粒pBR322 DNA进行了光裂解。由于已观察到[ 1 ] 3+和[ 2 ] 3+的相似光解作用，因此所有带有4,4'-联吡啶阳离子的偶极钌（II）胺络合物都可以作为O 2起作用。-独立的光化学治疗剂。
• μ-1,2,4,5-Tetrazine-N1:N4-bis(pentaammineruthenium) tetracation: Synthesis and X-ray structure
  作者：Silvia Tampucci、Marisa Belicchi Ferrari、Lucia Calucci、Giorgio Pelosi、Gianfranco Denti

  DOI：10.1016/j.ica.2006.12.044

  日期：2007.5

  The 2:1 reaction of [Ru(H2O)(2)(NH3)(5)](2+) with 1,2,4,5-tetrazine (tz) gives rise to the formation of the dinuclear complex ion [Ru(NH3)(5)}(2)(mu-tz-N-1:N-4)](4+). Its tetraphenylborate and hexafluoro-phosphate salts have been fully characterized; the X-ray structure of the former has also been determined. (C) 2007 Elsevier B.V. All rights reserved.