2,4-二甲氧基-6-苯基-1,3,5-三嗪 | 18213-73-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 中文名称: 2,4-二甲氧基-6-苯基-1,3,5-三嗪
• 英文名称: 2,4-dimethoxy-6-phenyl-1,3,5-triazine
• 英文别名: 2-phenyl-4,6-dimethoxy-1,3,5-triazine；2,4-dimethoxy-6-phenyltriazine；2,4-dimethoxy-6-phenyl-[1,3,5]triazine；dimethoxy-phenyl-[1,3,5]triazine；Dimethoxy-phenyl-[1,3,5]triazin；2,4-Dimethoxy-6-phenyl-1,3,5-triazin
• CAS: 18213-73-5
• 化学式: C₁₁H₁₁N₃O₂
• 分子量: 217.227
• InChiKey: MBOHQAALDUADLU-UHFFFAOYSA-N

物化性质

• 沸点：
  380.3±25.0 °C(Predicted)
• 密度：
  1.190±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  57.1
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2933699090

反应信息

• 作为产物：
  描述：

  phenylmagnesium bromide 在 sodium hydroxide 、 乙醚 作用下， 生成 2,4-二甲氧基-6-苯基-1,3,5-三嗪
  参考文献：
  名称：

  Grundmann et al., Chemische Berichte, 1953, vol. 86, p. 181,184

  摘要：

  DOI：

文献信息

• Iron catalyzed cross coupling reactions of aromatic compounds
  申请人：——

  公开号：US20030220498A1

  公开（公告）日：2003-11-27

  A process for the production of compounds Ar—R 1 by means of a cross-coupling reaction of an organometallic reagent R 1 —M with an aromatic or heteroaromatic substrate Ar—X catalyzed by one or several iron salts or iron complexes as catalysts or pre-catalysts, present homogeneously or heterogeneously in the reaction mixture. This new invention exhibits substantial advantages over established cross coupling methodology using palladium- or nickel complexes as the catalysts. Most notable aspects are the fact that (i) expensive and/or toxic nobel metal catalysts are replaced by cheap, stable, commercially available and toxicologically benign iron salts or iron complexes as the catalysts or pre-catalysts, (ii) commercially attractive aryl chlorides as well as various aryl sulfonates can be used as starting materials, (iii) the reaction can be performed under “ligand-free” conditons, and (iv) the reaction times are usually very short.

  通过使用一种或多种铁盐或铁络合物作为催化剂或前催化剂，在有机金属试剂R1—M与芳香或杂芳底物Ar—X之间进行交叉偶联反应的方法，生产化合物Ar—R1。这一新发明相对于使用钯或镍络合物作为催化剂的传统交叉偶联方法具有显著优势。最值得注意的方面包括：(i) 昂贵和/或有毒的贵金属催化剂被廉价、稳定、商业可获得且毒理学上良性的铁盐或铁络合物替代作为催化剂或前催化剂，(ii) 商业上具吸引力的芳基氯化物以及各种芳基磺酸盐可用作起始材料，(iii) 反应可在“无配体”条件下进行，(iv) 反应时间通常非常短。
• Iron-Catalyzed Cross-Coupling Reactions
  作者：Alois Fürstner、Andreas Leitner、María Méndez、Helga Krause

  DOI：10.1021/ja027190t

  日期：2002.11.1

  and -CF(3) groups are compatible. The method also allows for consecutive cross-coupling processes in one pot, as exemplified by the efficient preparation of compound 12, and has been applied to the first synthesis of the cytotoxic marine natural product montipyridine 8. In contrast to the clean reaction of (hetero)aryl chlorides, the corresponding bromides and iodides are prone to a reduction of their

  简单的铁盐，如 FeCl(n)、Fe(acac)(n) (n = 2,3) 或 salen 络合物 4 被证明是高效、廉价、毒理学无害且环境友好的预催化剂，可用于许多交叉- 烷基或芳基格氏试剂、锌酸盐或有机锰物质与芳基和杂芳基氯化物、三氟甲磺酸盐甚至甲苯磺酸盐的偶联反应。原位制备的正式成分 [Fe(MgX)(2)] 的“无机格氏试剂”可能构成负责催化周转的传播物种，在许多情况下，即使在室温或室温以下，这种转化率也以前所未有的速度发生。由于反应条件异常温和，一系列官能团如酯、醚、腈、磺酸盐、磺酰胺、硫醚、缩醛、炔烃和 -CF(3) 基团是相容的。
• Nickel-Catalyzed Suzuki–Miyaura Coupling of Heteroaryl Ethers with Arylboronic Acids
  作者：Xiao-Jian Li、Jin-Ling Zhang、Yu Geng、Zhong Jin

  DOI：10.1021/jo4005537

  日期：2013.5.17

  Nickel-catalyzed Suzuki–Miyaura coupling of heteroaryl ethers with arylboronic acids was described. Selective activation of the phenol C–O bonds was achieved by converting them into the corresponding aryl 2,4-dimethoxy-1,3,5-triazine-6-yl ethers, in which aryl C–O bond could be selectively cleaved with inexpensive, air-stable NiCl2(dppf) as a catalyst. Coupling of these readily accessible heteroaryl

  镍催化杂芳基醚与芳基硼酸的铃木-宫浦偶合。苯酚C-O键的选择性活化是通过将其转化为相应的芳基2,4-二甲氧基-1,3,5-三嗪-6-基醚来实现的，其中芳基C-O键可以用廉价的方法选择性裂解。 ，空气稳定的NiCl 2（dppf）作为催化剂。这些易于获得的杂芳基醚的偶联被证明对广泛的官能团具有耐受性。
• Novel cross-coupling reactions between organotellurides and Grignard reagents employing a MnCl2/CuI catalytic system
  作者：Marcio S. Silva、Renan S. Ferrarini、Bruno A. Sousa、Fabiano T. Toledo、João V. Comasseto、Rogério A. Gariani

  DOI：10.1016/j.tetlet.2012.04.134

  日期：2012.7

  We present a general protocol for the cross-coupling reaction of Grignard reagents and organic tellurides. Aryl Grignard reagents react stereospecifically with vinyl tellurides in the presence of a catalytic amount of manganese (II) chloride and copper (I) iodide to produce good yields of the corresponding cross-coupling products.

  我们提出了格氏试剂和有机碲化物交叉偶联反应的一般方案。在催化量的氯化锰（II）和碘化铜（I）的存在下，芳基格氏试剂与碲化乙烯立体定向反应，从而产生相应交叉偶联产物的良好收率。
• Thermally activatable, fast curing adhesive coating
  申请人：UNIVERSITÄT KASSEL

  公开号：US10711169B2

  公开（公告）日：2020-07-14

  The present invention relates to a thermally activatable adhesive composition for use in a method for producing a stack of metal sheets from glued together sheet metal components, the use of the adhesive composition in a method for producing a stack of metal sheets from glued together sheet metal components, the method for producing a stack of metal sheets from glued together sheet metal components, a sheet metal component coated with the adhesive composition, and a stator or rotor core containing one or more of such sheet metal components.

  本发明涉及一种可热活化的粘合剂组合物，该粘合剂组合物可用于用粘合在一起的金属薄板部件生产金属薄板叠片的方法；该粘合剂组合物可用于用粘合在一起的金属薄板部件生产金属薄板叠片的方法；该用粘合在一起的金属薄板部件生产金属薄板叠片的方法；涂有该粘合剂组合物的金属薄板部件；以及包含一个或多个此类金属薄板部件的定子或转子铁芯。