3-Methyl-2-trimethylsilanyloxy-butyraldehyde | 112969-05-8

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 3-Methyl-2-trimethylsilanyloxy-butyraldehyde
• 英文别名: 3-Methyl-2-[(trimethylsilyl)oxy]butanal；3-methyl-2-trimethylsilyloxybutanal
• CAS: 112969-05-8
• 化学式: C₈H₁₈O₂Si
• 分子量: 174.315
• InChiKey: CGZNFZJVGIPQFE-UHFFFAOYSA-N

物化性质

• 沸点：
  161.0±23.0 °C(Predicted)
• 密度：
  0.868±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.06
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  ((2R,3S)-3-Isopropyl-oxiranyl)-trimethyl-silane 在 4-硝基吡啶-N-氧化物 、 三氟甲磺酸三甲基硅酯 作用下， 反应 4.5h， 以33%的产率得到3-Methyl-2-trimethylsilanyloxy-butyraldehyde
  参考文献：
  名称：

  Oxidation of an αβ-(epoxyalkyl)trimethylsilane with pyridine oxides in the presence of silylating agents. A facile enantioselective synthesis of glyceraldehyde derivatives

  摘要：

  Trimethylsilyl glycidol derivatives 1 were oxidized with pyridine N-oxides in the presence of silylating agents to give the corresponding glyceraldehyde derivatives 3. Reaction of (alpha,beta-epoxyallcyl)silanes with N-oxides was studied.

  DOI：

  10.1016/s0040-4039(00)76915-2

文献信息

• The mechanism of the formation of silyl enol ethers from hydrosilanes and organic carbonyl compounds in the presence of cobalt carbonyls. Kinetic investigation of some reaction steps
  作者：Istvan. Kovacs、Attila. Sisak、Ferenc. Ungvary、Laszlo. Marko

  DOI：10.1021/om00095a002

  日期：1988.5.1
• Raubo Piotr, Wicha Jerzy, Tetrahedron Lett, 35 (1994) N 20, S 3387-3390
  作者：Raubo Piotr, Wicha Jerzy

  DOI：——

  日期：——
• KOVACS, ISTVAN;SISAK, ATTILA;UNGVARY, FERENC;MARKO, LASZLO, ORGANOMETALLICS, 7,(1988) N 5, 1025-1028
  作者：KOVACS, ISTVAN、SISAK, ATTILA、UNGVARY, FERENC、MARKO, LASZLO

  DOI：——

  日期：——
• Oxidation of an αβ-(epoxyalkyl)trimethylsilane with pyridine oxides in the presence of silylating agents. A facile enantioselective synthesis of glyceraldehyde derivatives
  作者：Piotr Raubo、Jerzy Wicha

  DOI：10.1016/s0040-4039(00)76915-2

  日期：1994.5

  Trimethylsilyl glycidol derivatives 1 were oxidized with pyridine N-oxides in the presence of silylating agents to give the corresponding glyceraldehyde derivatives 3. Reaction of (alpha,beta-epoxyallcyl)silanes with N-oxides was studied.