8-hydroxy-1,3-dimethyl-4H-cyclohepta[c]furan-4-one | 202581-68-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环七呋喃
• 英文名称: 8-hydroxy-1,3-dimethyl-4H-cyclohepta[c]furan-4-one
• 英文别名: 8-hydroxy-1,3-dimethylcyclohepta[c]furan-4-one；4-hydroxy-1,3-dimethylcyclohepta[c]furan-8-one
• CAS: 202581-68-8
• 化学式: C₁₁H₁₀O₃
• 分子量: 190.199
• InChiKey: UHUVMZAZSQBMOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  50.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-hydroxy-1,3-dimethyl-4H-cyclohepta[c]furan-4-one 在 氢溴酸 作用下， 以 乙醚 为溶剂， 以76%的产率得到C₁₁H₁₁O₃⁽¹⁺⁾*Br^(1-)
  参考文献：
  名称：

  Olekhnovich; Boroshko; Borodkin, Russian Journal of Organic Chemistry, 1997, vol. 33, # 2, p. 234 - 242

  摘要：

  DOI：
• 作为产物：
  描述：

  8-Ethoxy-1,3-dimethyl-cyclohepta[c]furan-4-one 在 高氯酸 作用下， 反应 0.12h， 以94.2%的产率得到8-hydroxy-1,3-dimethyl-4H-cyclohepta[c]furan-4-one
  参考文献：
  名称：

  Olekhnovich; Boroshko; Borodkin, Russian Journal of Organic Chemistry, 1997, vol. 33, # 2, p. 234 - 242

  摘要：

  DOI：

文献信息

• Synthesis of novel tricyclic 2H,7H-furo[3′,4′:6,7]cyclohepta-[1,2-b]pyran system
  作者：M. Yu. Arsenyeva、V. G. Arsenyev

  DOI：10.1007/s10593-009-0199-5

  日期：2008.11

  The reaction of 8-hydroxy-1,3-dimethyl-4H-cyclohepta[c]furan-4-one with the ethoxymethylene derivatives of malononitrile or ethyl cyanoacetate in the presence of KOH gave noncyclic cyanovinyl derivatives as their potassium salts rather than the expected alpha-pyrone derivatives. They are smoothly cyclized to the target alpha-pyrones by refluxing with acid. The corresponding 3-benzamido-2H-pyran-2-ones can be obtained in a single vessel from the 2-aryl-4-ethoxymethylene-4H-1,3-oxazol-5-ones using the same scheme.
• Synthesis of derivatives of the new condensed system 4H,7H-furo[3′,4′:6,7]cyclohepta[1,2-b]pyran
  作者：M. Yu. Arsen’eva、V. G. Arsen’ev

  DOI：10.1007/s10593-008-0037-1

  日期：2008.2

  8-Hydroxy-1,3-dimethyl-4H-cyclohepta[c]furan-4-one reacts with arylidenemalononitriles and, like 1,3-oxo enols, forms the corresponding condensed 2-amino-4H-pyrans. The analogous reaction with 3-(dicyanomethylene)indolin-2-ones give spirocyclic 2-amino-4H-pyrans. The 4-aminopyrimidine ring is formed on the basis of the enamino nitrile fragment of the new pyrans by successive reaction with triethoxymethane and then with aqueous ammonia.
• Olekhnovich; Boroshko; Borodkin, Russian Journal of Organic Chemistry, 1997, vol. 33, # 2, p. 234 - 242
  作者：Olekhnovich、Boroshko、Borodkin、Korobka、Minkin、Olekhnovich

  DOI：——

  日期：——