6-fluoro-3-[1-[(2-pyrimidinoxy)-propyl]-4-piperidinyl]-1,2-benzisoxazole fumarate | 167266-44-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并异恶唑
• 英文名称: 6-fluoro-3-[1-[(2-pyrimidinoxy)-propyl]-4-piperidinyl]-1,2-benzisoxazole fumarate
• 英文别名: (E)-but-2-enedioic acid;6-fluoro-3-[1-(3-pyrimidin-2-yloxypropyl)piperidin-4-yl]-1,2-benzoxazole
• CAS: 167266-44-6
• 化学式: C₄H₄O₄*C₁₉H₂₁FN₄O₂
• 分子量: 472.473
• InChiKey: YQCFJTHHQUXBOR-WLHGVMLRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.12
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  139
• 氢给体数：
  2
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  2-氯嘧啶 、 diethylamine-ethyl acetate 、 双(三甲基硅烷基)氨基钾 、 富马酸 、 帕潘立酮杂质1 生成 6-fluoro-3-[1-[(2-pyrimidinoxy)-propyl]-4-piperidinyl]-1,2-benzisoxazole fumarate
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics.
  申请人：Aventis Pharmaceuticals Inc.

  公开号：EP1052255A1

  公开（公告）日：2000-11-15

  Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.

  杂环芳基哌啶、吡咯烷和哌嗪可用作抗精神病和镇痛剂。这些化合物尤其适用于通过向哺乳动物投与化合物的精神病治疗有效量来治疗精神病。这些化合物也可通过向哺乳动物投与化合物的镇痛有效量来用作镇痛剂。
• Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics
  申请人：Aventis Pharmaceuticals Inc.

  公开号：EP2311824A1

  公开（公告）日：2011-04-20

  Heteroarylpiperidines, pyrrolidines, and piperazines of the formula wherein X is -O-, -S-, -NH-, or -N(R2)- R2 is selected from the group consisting of lower alkyl, aryl lower alkyl, aryl, cycloalkyl, aroyl, alkanoyl, alkoxycarbonyl and phenylsulfonyl groups; p is 1 or 2 Y is hydrogen, lower alkyl, hydroxy, chlorine, fluorine, bromine, iodine, lower alkoxy, trifluoromethyl, nitro, or amino; Q1 is selected from the group consisting of: and where Z is are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.

  式中X为-O-，-S-，-NH-或-N（R2）-，R2选自下列组：低烷基，芳基低烷基，芳基，环烷基，芳香酰基，烷酰基，烷氧羰基和苯基磺酰基基团；p为1或2；Y为氢，低烷基，羟基，氯，氟，溴，碘，低烷氧基，三氟甲基，硝基或氨基；Q1选自下列组：其中Z为，本发明化合物作为抗精神病和镇痛剂具有应用价值。该化合物特别适用于通过向哺乳动物施用化合物的精神病治疗有效量来治疗精神病。该化合物的沉积物衍生物可用于提供化合物的长效作用。该化合物也可通过向哺乳动物施用缓解疼痛的有效量的化合物来用作镇痛剂。
• Heteroarylpiperidines and piperazines and their use as antipsychotics and analgetics
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0957102A1

  公开（公告）日：1999-11-17

  Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.

  杂环芳基哌啶、吡咯烷和哌嗪类化合物可作为抗精神病和镇痛药剂。这些化合物特别适用于通过向哺乳动物投与其中一种化合物的精神病治疗有效量来治疗精神病。同时，通过向哺乳动物投与其中一种化合物的止痛有效量，这些化合物也可作为止痛药剂。
• [EN] HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS<br/>[FR] HETEROARYLPIPERIDINES, PYRROLIDINES ET PIPERAZINES ET LEUR UTILISATION COMME ANTIPSYCHOTIQUES ET ANALGESIQUES
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INC.

  公开号：WO1995011680A1

  公开（公告）日：1995-05-04

  (EN) Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.(FR) Hétéroarylpipéridines, pyrrolidines et pipérazines utilisés comme antipsychotiques et analgésiques. Ces composés s'avèrent particulièrement utiles dans le traitement des psychoses des mammifères, qui s'opère par administration de doses à effet traitant de l'un d'eux. Leurs dérivés par déposition leur confèrent une efficacité de longue durée. Ils s'avèrent également efficaces comme analgésiques lorsque l'un d'eux est administré en doses à effet traitant.

  Heteroarylpiperidines、pyrrolidines和piperazines作为抗精神病和镇痛药物非常有用。这些化合物特别适用于通过给哺乳动物注射其中一种化合物的精神病治疗有效量来治疗精神病。这些化合物的长效衍生物对于提供化合物的长效作用非常有用。当给哺乳动物注射一种镇痛有效量的化合物时，这些化合物也非常有用作为镇痛剂。
• Heteroarylperidines and piperazines and their use as antipsychotics and analgetics
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0959076A1

  公开（公告）日：1999-11-24

  Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.

  杂芳基哌啶类、吡咯烷类和哌嗪类化合物可用作抗精神病药和镇痛药。通过向哺乳动物施用有效量的其中一种化合物，这些化合物尤其可用于治疗精神病。通过向哺乳动物施用有效量的其中一种化合物，这些化合物还可用作镇痛剂。