1-[(3-Chlorophenyl)-(2,4,5-trimethoxyphenyl)methyl]-2,4,5-trimethoxybenzene | 1236811-18-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-[(3-Chlorophenyl)-(2,4,5-trimethoxyphenyl)methyl]-2,4,5-trimethoxybenzene
• CAS: 1236811-18-9
• 化学式: C₂₅H₂₇ClO₆
• 分子量: 458.939
• InChiKey: LLGUYXZNSCNECW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,2,4-三甲氧基苯 、 N-[(3-氯苯基)亚甲基]-4-甲基苯磺酰胺 在 iron(III) chloride hexahydrate 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 以82%的产率得到1-[(3-Chlorophenyl)-(2,4,5-trimethoxyphenyl)methyl]-2,4,5-trimethoxybenzene
  参考文献：
  名称：

  Friedel−Crafts Arylation Reactions of N-Sulfonyl Aldimines or Sulfonamidesulfones with Electron-Rich Arenes Catalyzed by FeCl₃·6H₂O: Synthesis of Triarylmethanes and Bis-heteroarylarylmethanes

  摘要：

  The FeCl3 center dot 6H(2)O-catalyzed Friedel-Crafts arylation reactions of N-sulfonyl aldimines or sulfonamidesulfones with electron-rich arenes and heteroarenes, which lead to the formation of triarylmethanes and bis-heteroarylarylmethanes, are developed. The use of mild reaction conditions, low catalytic loading, high yield, and single step synthesis are the advantages of the present procedure.

  DOI：

  10.1021/jo1010137

文献信息

• Friedel−Crafts Arylation Reactions of <i>N</i>-Sulfonyl Aldimines or Sulfonamidesulfones with Electron-Rich Arenes Catalyzed by FeCl₃·6H₂O: Synthesis of Triarylmethanes and Bis-heteroarylarylmethanes
  作者：Ponnaboina Thirupathi、Sung Soo Kim

  DOI：10.1021/jo1010137

  日期：2010.8.6

  The FeCl3 center dot 6H(2)O-catalyzed Friedel-Crafts arylation reactions of N-sulfonyl aldimines or sulfonamidesulfones with electron-rich arenes and heteroarenes, which lead to the formation of triarylmethanes and bis-heteroarylarylmethanes, are developed. The use of mild reaction conditions, low catalytic loading, high yield, and single step synthesis are the advantages of the present procedure.