(1R,2R)-1-(biphenyl-4-ylmethylamino)-1-phenyl-3-(trityloxy)propan-2-ol | 1016549-67-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (1R,2R)-1-(biphenyl-4-ylmethylamino)-1-phenyl-3-(trityloxy)propan-2-ol
• 英文别名: (1R,2R)-1-phenyl-1-[(4-phenylphenyl)methylamino]-3-trityloxypropan-2-ol
• CAS: 1016549-67-9
• 化学式: C₄₁H₃₇NO₂
• 分子量: 575.75
• InChiKey: BWBCKKAHMRVZJB-IOLBBIBUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.4
• 重原子数：
  44
• 可旋转键数：
  12
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氨基乙基联苯 、 Oxirane, 2-phenyl-3-[(triphenylmethoxy)methyl]-, (2S,3S)- 在 lithium perchlorate 作用下， 以 乙腈 为溶剂， 以83%的产率得到(1R,2R)-1-(biphenyl-4-ylmethylamino)-1-phenyl-3-(trityloxy)propan-2-ol
  参考文献：
  名称：

  Aqueous asymmetric transfer hydrogenation using modular hydrophobic aminoalcohols

  摘要：

  A series of new modular Ru/aminoalcohol systems were used as enantioselective catalysts in the asymmetric transfer hydrogenation reaction in both water and 2-propanol. The catalytic behavior exhibited in these two media follows different tendencies regarding the tunable ligand structure. While the bulkiness of the R-1 group has a positive effect on the activity for reactions in 2-propanol, ligands with bulky R-1 groups are generally less active in water. Additionally, cationic, anionic, and neutral surfactants do not improve the catalytic behavior in water. 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.01.001

文献信息

• Aqueous asymmetric transfer hydrogenation using modular hydrophobic aminoalcohols
  作者：Esther Alza、Amaia Bastero、Susanna Jansat、Miquel A. Pericàs

  DOI：10.1016/j.tetasy.2008.01.001

  日期：2008.2

  A series of new modular Ru/aminoalcohol systems were used as enantioselective catalysts in the asymmetric transfer hydrogenation reaction in both water and 2-propanol. The catalytic behavior exhibited in these two media follows different tendencies regarding the tunable ligand structure. While the bulkiness of the R-1 group has a positive effect on the activity for reactions in 2-propanol, ligands with bulky R-1 groups are generally less active in water. Additionally, cationic, anionic, and neutral surfactants do not improve the catalytic behavior in water. 2008 Elsevier Ltd. All rights reserved.