N-[2-(tritylamino)ethyl]benzamide | 1446714-11-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: N-[2-(tritylamino)ethyl]benzamide
• CAS: 1446714-11-9
• 化学式: C₂₈H₂₆N₂O
• 分子量: 406.527
• InChiKey: RHNXHXVGBUQYCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(2-氨基乙基)苯甲酰胺 、 三苯基氯甲烷 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以87%的产率得到N-[2-(tritylamino)ethyl]benzamide
  参考文献：
  名称：

  Cyclodehydration of N-(Aminoalkyl)benzamides under Mild Conditions with a Hendrickson Reagent Analogue

  摘要：

  Methods for the cydodehydration of N-(aminoalkyl)benzamides are few and employ harsh reaction conditions. We have found that the easily prepared phosphonium anhydrides 1 (Hendrickson reagent) or 2 can be used for cyclodehydration of N-(aminoalkyl)benzamides under very mild conditions (room temperature) to produce five-, six-, and seven-membered cyclic amidines. Good yields are obtained by employing a temporary trityl group protection strategy. Cyclic analogue 2 can be used when the product cyclic amidine is organic-soluble, thus producing water-soluble byproducts.

  DOI：

  10.1021/jo401082q

文献信息

• Antibacterial agents
  申请人：Andersen Niels H.

  公开号：US20090247506A1

  公开（公告）日：2009-10-01

  Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.

  提供式I的抗菌化合物：以及其立体异构体，药学上可接受的盐，酯和前药；包括这些化合物的药物组合物；通过给予这些化合物的途径来治疗细菌感染的方法；以及制备这些化合物的过程。
• Cyclodehydration of <i>N</i>-(Aminoalkyl)benzamides under Mild Conditions with a Hendrickson Reagent Analogue
  作者：Wendy A. Loughlin、Ian D. Jenkins、Maria J. Petersson

  DOI：10.1021/jo401082q

  日期：2013.7.19

  Methods for the cydodehydration of N-(aminoalkyl)benzamides are few and employ harsh reaction conditions. We have found that the easily prepared phosphonium anhydrides 1 (Hendrickson reagent) or 2 can be used for cyclodehydration of N-(aminoalkyl)benzamides under very mild conditions (room temperature) to produce five-, six-, and seven-membered cyclic amidines. Good yields are obtained by employing a temporary trityl group protection strategy. Cyclic analogue 2 can be used when the product cyclic amidine is organic-soluble, thus producing water-soluble byproducts.