12-[Bis(4-methoxyphenyl)-phenylmethoxy]dodecanoic acid | 253877-42-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 12-[Bis(4-methoxyphenyl)-phenylmethoxy]dodecanoic acid
• CAS: 253877-42-8
• 化学式: C₃₃H₄₂O₅
• 分子量: 518.693
• InChiKey: YFMDKHQEBVNDEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  38
• 可旋转键数：
  18
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  12-[Bis(4-methoxyphenyl)-phenylmethoxy]dodecanoic acid 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells

  摘要：

  Double-stranded short interfering RNAs (siRNAs) mediate post-transcriptional inhibition of gene expression in a variety of biological systems. However, human liver cells show poor uptake of these nucleic acids. In order to improve the delivery of siRNA into these cells without transfection agents, we have synthesized two series of lipophilic siRNAs conjugated with derivatives of cholesterol, lithocholic acid or lauric acid. The lipid moieties were covalently linked to the 5'-ends of the RNAs using phosphoramidite chemistry. The potency of these chemically modified siRNAs to inhibit reporter gene expression was further investigated in vitro with beta-galactosidase expressing liver cells. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.07.018
• 作为产物：
  描述：

  12-羟基十二酸 、 4,4'-双甲氧基三苯甲基氯 在 吡啶 作用下， 生成 12-[Bis(4-methoxyphenyl)-phenylmethoxy]dodecanoic acid
  参考文献：
  名称：

  Molecular beacons attached to glass beads fluoresce upon hybridisation to target DNA

  摘要：

  附着在玻璃珠上的分子信标已被 合成的，在暴露于互补物之前是非荧光的 目标核酸，因此它们发出荧光，表明 杂交。

  DOI：

  10.1039/b000389l

文献信息

• Molecular beacons attached to glass beads fluoresce upon hybridisation to target DNA
  作者：Lynda J. Brown、Tom Brown、Jon Cummins、Alan Hamilton

  DOI：10.1039/b000389l

  日期：——

  Molecular beacons attached to glass beads have been synthesised which are non-fluorescent until exposed to a complementary target nucleic acid, whereupon they fluoresce, indicating hybridisation.

  附着在玻璃珠上的分子信标已被 合成的，在暴露于互补物之前是非荧光的 目标核酸，因此它们发出荧光，表明 杂交。
• Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells
  作者：Christina Lorenz、Philipp Hadwiger、Matthias John、Hans-Peter Vornlocher、Carlo Unverzagt

  DOI：10.1016/j.bmcl.2004.07.018

  日期：2004.10

  Double-stranded short interfering RNAs (siRNAs) mediate post-transcriptional inhibition of gene expression in a variety of biological systems. However, human liver cells show poor uptake of these nucleic acids. In order to improve the delivery of siRNA into these cells without transfection agents, we have synthesized two series of lipophilic siRNAs conjugated with derivatives of cholesterol, lithocholic acid or lauric acid. The lipid moieties were covalently linked to the 5'-ends of the RNAs using phosphoramidite chemistry. The potency of these chemically modified siRNAs to inhibit reporter gene expression was further investigated in vitro with beta-galactosidase expressing liver cells. (C) 2004 Elsevier Ltd. All rights reserved.