5-methoxy-4-azatricyclo[4.3.1.1^3,8]undec-4-ene | 31556-14-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吖庚因类
• 英文名称: 5-methoxy-4-azatricyclo[4.3.1.1^3,8]undec-4-ene
• 英文别名: 5-methoxy-4-azatricyclo[4.3.1.1(3,8)]undec-4-ene；5-methoxy-4-aza-tricyclo[4.3.1.1^3,8]undec-4-ene；5-Methoxy-4-azahomoadamant-4-en；5-Methoxy-4-azatricyclo[4.3.1.1,3,8]undec-4-ene；5-methoxy-4-azatricyclo[4.3.1.13,8]undec-4-ene
• CAS: 31556-14-6
• 化学式: C₁₁H₁₇NO
• 分子量: 179.262
• InChiKey: DBMXMUPFZFEQGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-methoxy-4-azatricyclo[4.3.1.1^3,8]undec-4-ene 以 乙醇 为溶剂， 反应 8.0h， 生成 3-methoxy-6,7,8,9,10,11-hexahydro-5H-5,9:7,11-dimethano[1,2,4]triazolo[4,3-a]azonine
  参考文献：
  名称：

  Interaction of 5-methoxy-4-azatricyclo[4.3.1.13,8]-undec-4-ene with nitrogen-containing nucleophiles

  摘要：

  The interaction of 5-methoxy-4-azatricyclo[4.3.1.1(3,8)]undec-4-ene with acid hydrazides has been studied. It has been established that its reaction with methoxycarbonylhydrazine leads to the formation of 6,7,8,9,10,11-hexahydro-5H-5,9:7,11-dimethano[1,2,4]triazolo[4,3-a]azocin-3-one. Special features of the alkylation of this substrate under various conditions have been studied.

  DOI：

  10.1007/s10593-013-1166-8
• 作为产物：
  描述：

  4-杂氮三环[4.3.1.13,8]十一烷-5-酮 、 三氟甲烷磺酸甲酯 以 二氯甲烷 为溶剂， 反应 0.33h， 以to afford crude 5-methoxy-4-azatricyclo[4.3.1.13,8]undec-4-ene 3-B which的产率得到5-methoxy-4-azatricyclo[4.3.1.1^3,8]undec-4-ene
  参考文献：
  名称：

  Triazole derivatives as inhibitors of 11-β hydroxysteroid dehydrogenase-1

  摘要：

  结构式为I的三唑衍生物是11β-羟基类固醇脱氢酶-1的选择性抑制剂。这些化合物可用于治疗糖尿病，如非胰岛素依赖性糖尿病（NIDDM）、高血糖、肥胖症、胰岛素抵抗、血脂异常、高脂血症、高血压、代谢综合症和与NIDDM相关的其他症状。

  公开号：

  US08026264B2

文献信息

• Triazole derivatives as inhibitors of 11-beta hydroxysteroid dehydrogenase-1
  申请人：Waddell T. Sherman

  公开号：US20060258695A1

  公开（公告）日：2006-11-16

  Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM.

  结构式I的三唑衍生物是11β-羟基类固醇脱氢酶-1的选择性抑制剂。这些化合物可用于治疗糖尿病，如非胰岛素依赖性糖尿病（NIDDM）、高血糖、肥胖症、胰岛素抵抗、血脂异常、高脂血症、高血压、代谢综合征和与NIDDM相关的其他症状。
• Synthesis of 3-r-6,7,8,9,10,11-hexahydro-5H-5,9:7,11-dimethano[1,2,4]triazolo[4,3-a]azocines
  作者：E. A. Knyazeva、M. Yu. Skomorohov、Yu. N. Klimochkin

  DOI：10.1007/s10593-011-0680-9

  日期：2011.2
• Derivatives of 4-azahomoadamantane. Their synthesis and biological evaluation
  作者：J. G. Korsloot、V. G. Keizer

  DOI：10.1021/jm00287a009

  日期：1971.5
• Interaction of 5-methoxy-4-azatricyclo[4.3.1.13,8]-undec-4-ene with nitrogen-containing nucleophiles
  作者：E. A. Knyazeva、M. Yu. Skomorokhov、D. V. Osipov、Yu. N. Klimochkin

  DOI：10.1007/s10593-013-1166-8

  日期：2013.1

  The interaction of 5-methoxy-4-azatricyclo[4.3.1.1(3,8)]undec-4-ene with acid hydrazides has been studied. It has been established that its reaction with methoxycarbonylhydrazine leads to the formation of 6,7,8,9,10,11-hexahydro-5H-5,9:7,11-dimethano[1,2,4]triazolo[4,3-a]azocin-3-one. Special features of the alkylation of this substrate under various conditions have been studied.
• Triazole derivatives as inhibitors of 11-β hydroxysteroid dehydrogenase-1
  申请人：Merck Sharp and Dohme Corp.

  公开号：US08026264B2

  公开（公告）日：2011-09-27

  Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM.

  结构式为I的三唑衍生物是11β-羟基类固醇脱氢酶-1的选择性抑制剂。这些化合物可用于治疗糖尿病，如非胰岛素依赖性糖尿病（NIDDM）、高血糖、肥胖症、胰岛素抵抗、血脂异常、高脂血症、高血压、代谢综合症和与NIDDM相关的其他症状。