5-amino-O-(4,4'-dimethoxytrityl)pentan-1-ol | 129185-29-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5-amino-O-(4,4'-dimethoxytrityl)pentan-1-ol
• 英文别名: O-4,4'-dimethoxytrityl-5-aminopentan-1-ol；5-(4,4'-dimethoxytrityloxy)pentylamine；O-(4,4'-dimethoxytrityl)-5-aminopentan-1-ol；5-[bis(4-methoxyphenyl)-phenylmethoxy]pentan-1-amine
• CAS: 129185-29-1
• 化学式: C₂₆H₃₁NO₃
• 分子量: 405.537
• InChiKey: SOGXZTATSANEGJ-UHFFFAOYSA-N

物化性质

• 沸点：
  530.5±50.0 °C(Predicted)
• 密度：
  1.086±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  53.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-amino-O-(4,4'-dimethoxytrityl)pentan-1-ol 生成 [(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl 5-(3-sulfanylpropanoylamino)pentyl hydrogen phosphate
  参考文献：
  名称：

  GUPTA, K. C.;SHARMA, P.;SATHYANARAYANA, S.;KUMAR, P., TETRAHEDRON LETT., 31,(1990) N7, C. 2471-2474

  摘要：

  DOI：
• 作为产物：
  描述：

  9H-芴-9-基甲基(5-羟基戊基)氨基甲酸酯 在 吗啉 、 吡啶 作用下， 生成 5-amino-O-(4,4'-dimethoxytrityl)pentan-1-ol
  参考文献：
  名称：

  A universal solid support for the synthesis of 3′-thiol group containing oligonucleotides

  摘要：

  DOI：

  10.1016/s0040-4039(00)97392-1

文献信息

• DNA containing phenanthroline- and phenanthrene-derived, non-nucleosidic base surrogates
  作者：Simon M. Langenegger、Robert Häner

  DOI：10.1016/j.tetlet.2004.10.068

  日期：2004.12

  Simple, non-nucleosidic phenanthroline- and phenanthrene derivatives have been synthesised and incorporated into oligodeoxynucleotides. Complementary strands containing the modified building blocks in opposite positions form stable hybrids. Thermal denaturation experiments show that the double strands containing the phenanthroline derivatives are more stable than the ones with the corresponding phenanthrenes

  已经合成了简单的非核苷菲咯啉和菲衍生物，并将其掺入寡脱氧核苷酸中。在相反位置包含修饰的构件的互补链形成稳定的杂种。热变性实验表明，含有菲咯啉衍生物的双链比具有相应菲的双链更稳定。此外，发现如果修饰的结构单元的接头太短，则双链体稳定性会大大降低。
• Phosphonylated fluorescent dyes and conjugates
  申请人：Lukhtanov Eugeny

  公开号：US20060199955A1

  公开（公告）日：2006-09-07

  Reagents are provided for the introduction of phosphonate groups into fluorescent dyes. Methods are also provided for preparing dye conjugates.

  提供试剂用于将膦酸酯基团引入荧光染料中。同时，还提供了制备染料偶联物的方法。
• PHOSPHONYLATED FLUORESCENT DYES AND CONJUGATES
  申请人：Lukhtanov Eugeny

  公开号：US20080207887A1

  公开（公告）日：2008-08-28

  Reagents are provided for the introduction of phosphonate groups into fluorescent dyes. Methods are also provided for preparing dye conjugates.

  试剂提供了将膦酸酯基团引入荧光染料中的方法。同时还提供了制备染料偶联物的方法。
• Phosphonate fluorescent dyes and conjugates
  申请人：Lukhtanov Eugeny

  公开号：US20070172832A1

  公开（公告）日：2007-07-26

  Reagents are provided for the introduction of phosphonate groups into fluorescent dyes. Methods are also provided for preparing dye conjugates.

  提供试剂用于将膦酸基团引入荧光染料中。同时还提供了制备染料共轭物的方法。
• PHOSPHONATE FLUORESCENT DYES AND CONJUGATES
  申请人：Lukhtanov Eugeny

  公开号：US20100261903A1

  公开（公告）日：2010-10-14

  Reagents are provided for the introduction of phosphonate groups into fluorescent dyes. Methods are also provided for preparing dye conjugates.

  试剂提供了将膦酸酯基团引入荧光染料中的方法。还提供了制备染料偶联物的方法。