Di-sec.-butylphosphinsaeurechlorid | 1112-22-7

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: Di-sec.-butylphosphinsaeurechlorid
• 英文别名: di-sec-butyl-phosphinoyl chloride；disec-butylphosphinyl chloride；2-[Butan-2-yl(chloro)phosphoryl]butane；2-[butan-2-yl(chloro)phosphoryl]butane
• CAS: 1112-22-7
• 化学式: C₈H₁₈ClOP
• 分子量: 196.657
• InChiKey: NHCKBRCJXVNYJA-UHFFFAOYSA-N

物化性质

• 沸点：
  285.4±9.0 °C(Predicted)
• 密度：
  0.998±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Di-sec.-butylphosphinsaeurechlorid 、 己基溴化镁 以 四氢呋喃 为溶剂， 反应 18.0h， 生成 1-di(sec-butyl)phosphinoylhexane
  参考文献：
  名称：

  Ophthalmic compositions and method for treating eye discomfort and pain

  摘要：

  通过给眼科溶液滴加含有三烷基氧化膦的创新组合物的眼药水，可以减少眼部不适。首选的给药方法是将溶液滴在闭合眼睛的内眼角，并保持眼睛闭合至少一分钟。优选的三烷基氧化膦是因为其强效性、长效性和无刺激性而被选择。为了进一步减少刺激性，可以向组合物中添加碳氢化合物聚醇或类似的润滑剂。在眼科溶液中的三烷基氧化膦的浓度最好在至少约0.001重量％至约0.5％（10μg/ml至5毫克/毫升）的组合物中。

  公开号：

  US20050059639A1
• 作为产物：
  描述：

  sec-BuMgBr 在 三氯氧磷 作用下， 生成 Di-sec.-butylphosphinsaeurechlorid
  参考文献：
  名称：

  Christen; van der Linde, Recueil des Travaux Chimiques des Pays-Bas, 1959, vol. 78, p. 543,546

  摘要：

  DOI：

文献信息

• beta-DIHYDROFURAN DERIVING COMPOUND, METHOD FOR PRODUCING beta-DIHYDROFURAN DERIVING COMPOUND OR beta-TETRAHYDROFURAN DERIVING COMPOUND, beta-GLYCOSIDE COMPOUND, METHOD FOR PRODUCING beta GLYCOSIDE COMPOUND, AND METHOD FOR PRODUCING 4'-ETHYNYL D4T AND ANALOGUE COMPOUNDS THEREOF
  申请人：Iriyama Yusuke

  公开号：US20120322995A1

  公开（公告）日：2012-12-20

  The invention provides a process for producing a β-dihydrofuran derivative represented by formula (1) or a β-tetrahydrofuran derivative represented by formula (4), characterized in that the process includes causing a dialkyl dicarbonate, a diaralkyl dicarbonate, or a halide to act on a diol compound represented by formula (2) or (3). The invention also provides a process for producing 4′-ethynyl-2′,3′-didehydro-3′-deoxythymidine or an analog thereof, the process including glycosylation and deprotection.

  该发明提供了一种生产由式（1）表示的β-二氢呋喃衍生物或由式（4）表示的β-四氢呋喃衍生物的过程，其特征在于该过程包括使二烷基二碳酸酯、二芳基二碳酸酯或卤化物作用于由式（2）或（3）表示的二醇化合物。该发明还提供了一种生产4'-乙炔基-2',3'-二去氢-3'-脱氧胸苷或其类似物的过程，包括糖基化和去保护。
• B-DIHYDROFURAN DERIVING COMPOUND, METHOD FOR PRODUCING B-DIHYDROFURAN DERIVING COMPOUND OR B-TETRAHYDROFURAN DERIVING COMPOUND, B -GLYCOSIDE COMPOUND, METHOD FOR PRODUCING B-GLYCOSIDE COMPOUND, AND METHOD FOR PRODUCING 4'-ETHYNYL D4T AND ANALOGUE COMPOUNDS THEREOF
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2537839A1

  公开（公告）日：2012-12-26

  The invention provides a process for producing a β-dihydrofuran derivative represented by formula (1) or a β-tetrahydrofuran derivative represented by formula (4), characterized in that the process includes causing a dialkyl dicarbonate, a diaralkyl dicarbonate, or a halide to act on a diol compound represented by formula (2) or (3). The invention also provides a process for producing 4'-ethynyl-2',3'-didehydro-3'-deoxythymidine or an analog thereof, the process including glycosylation and deprotection.

  本发明提供了一种生产由式(1)表示的β-二氢呋喃衍生物或由式(4)表示的β-四氢呋喃衍生物的工艺，其特征在于该工艺包括使二烷基二碳酸酯、二烷基二碳酸酯或卤化物作用于由式(2)或(3)表示的二元醇化合物。本发明还提供了一种生产 4'-乙炔基-2',3'-二脱氢-3'-脱氧胸苷或其类似物的工艺，该工艺包括糖基化和脱保护。
• de Roos; Toet, Recueil des Travaux Chimiques des Pays-Bas, 1959, vol. 78, p. 271,272
  作者：de Roos、Toet

  DOI：——

  日期：——
• Delivery Systems for Agents to treat Ocular Discomfort
  申请人：Wei Edward Tak

  公开号：US20150290029A1

  公开（公告）日：2015-10-15

  Eye drops are the traditional method for delivering drugs to the ocular surface but this method is considered inefficient and does not work well for soothing agents because sensory discomfort is evoked from the corneal surface by the pulsatile delivery of the agent. By contrast, eye wipes moistened with an evenly dispersed liquid composition of a soothing or cooling agent selectively delivers the active ingredient to receptors in the skin above the eyes, on the edges of the eyelids, and on the conjunctiva and do not evoke eye irritation. The delivered agent is now able to evoke sensations of refreshment and soothing on the ocular surface and to relieve eye discomfort.
• US9212174B2
  申请人：——

  公开号：US9212174B2

  公开（公告）日：2015-12-15