1,4-bis[(3,4,5-trihydroxybenzoyl)oxy]benzene | 188855-55-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: 1,4-bis[(3,4,5-trihydroxybenzoyl)oxy]benzene
• 英文别名: [4-(3,4,5-trihydroxybenzoyl)oxyphenyl] 3,4,5-trihydroxybenzoate
• CAS: 188855-55-2
• 化学式: C₂₀H₁₄O₁₀
• 分子量: 414.325
• InChiKey: WTCIFEKYDGGPNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  174
• 氢给体数：
  6
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  1,4-bis[(3,4,5-trihydroxybenzoyl)oxy]benzene 在 calcium bicarbonate 作用下， 以 叔丁醇 为溶剂， 以98.9 %的产率得到
  参考文献：
  名称：

  EP4253394

  摘要：

  公开号：
• 作为产物：
  描述：

  1,4-Phenylene bis<(3,4,5-tribenzyloxy)benzoate> 在 10 wt% Pd(OH)2 on carbon 、 氢气 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 20.0 ℃ 、344.75 kPa 条件下， 以80%的产率得到1,4-bis[(3,4,5-trihydroxybenzoyl)oxy]benzene
  参考文献：
  名称：

  New Synthetic Inhibitors of Fatty Acid Synthase with Anticancer Activity

  摘要：

  Fatty acid synthase (FASN) is a lipogenic enzyme that is highly expressed in different human cancers. Here we report the development of a new series of polyphenolic compounds 5-30 that have been evaluated for their cytotoxic capacity in SK-Br3 cells, a human breast cancer cell line with high FASN expression. The compounds with art IC50 < 50 mu M have been tested for their ability to inhibit FASN activity. Among them, derivative 30 blocks the 90% of FASN activity at low concentration (4 mu M), is highly cytotoxic in a broad panel of tumor cells, induces apoptosis, and blocks the activation of HER2, AKT, and ERK pathways. Remarkably, 30 does not activate carnitine palmitoyltransferase-1 (CPT-1) nor induces in mice weight loss, which are the main drawbacks of other previously described FASN inhibitors. Thus, FASN inhibitor 30 may aid the validation of this enzyme as a therapeutic target for the treatment of cancer.

  DOI：

  10.1021/jm2016045

文献信息

• Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism
  申请人：Lawrence Daniel A.

  公开号：US20100137194A1

  公开（公告）日：2010-06-03

  The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.

  本发明涉及纤溶酶原激活剂-1（PAI-1）抑制剂化合物及其在治疗任何与升高的PAI-1相关的疾病或病状中的应用。本发明包括但不限于使用这些化合物来调节脂质代谢并治疗与升高的PAI-1、胆固醇或脂质水平相关的病症。
• PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS AND METHODS OF USE THEREOF TO MODULATE LIPID METABOLISM
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20160009748A1

  公开（公告）日：2016-01-14

  The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.

  本发明涉及纤溶酶原激活物-1（PAI-1）抑制剂化合物及其在治疗与升高的PAI-1相关的任何疾病或病况中的用途。本发明包括但不限于使用这样的化合物来调节脂质代谢并治疗与升高的PAI-1、胆固醇或脂质水平相关的病症。
• 一种消杀试剂及其应用
  申请人：深圳市三启药物开发有限公司

  公开号：CN117603054A

  公开（公告）日：2024-02-27

  本发明涉及消杀试剂领域，具体涉及一种消杀试剂及其应用。所述消杀试剂包括星状化合物或其立体异构体、水合物、溶剂化物、药学可接受的盐、代谢物或前药，其具有抗微生物活性，对细菌、真菌具有杀灭和抑制效果，且对人体无毒无刺激，可单独使用，或与已知的消毒剂混合，降低已知消毒剂的使用浓度，制得无刺激、低毒性的消杀制剂。
• Synthesis of Poly(3,4,5-trihydroxybenzoate) dendrimers from Polyphenols and Their Chemiluminescence
  作者：Dai-Il Jung、Ju-Hyun Song、Eun-Hye Shin、Yun-Young Kim、Do-Hun Lee、Soon-Kyu Choi、Jung-Tai Hahn

  DOI：10.5012/bkcs.2010.31.04.1031

  日期：2010.4.20
• US9120744B2
  申请人：——

  公开号：US9120744B2

  公开（公告）日：2015-09-01