4-propyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane | 51486-55-6

• 分子结构分类: 有机化合物 - 有机磷化合物 - 亚磷酸三烷基酯
• 英文名称: 4-propyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane
• 英文别名: 1,3-Propanediol, 2-(hydroxymethyl)-2-isopropyl-, cyclic phosphite (1:1)；4-propan-2-yl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane
• CAS: 51486-55-6
• 化学式: C₇H₁₃O₃P
• 分子量: 176.152
• InChiKey: JKKXVCKZMHGQLJ-UHFFFAOYSA-N

物化性质

• 沸点：
  164.8±7.0 °C(Predicted)
• 保留指数：
  1327

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  phenyl azidoformate 、 4-propyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane 以 苯 为溶剂， 反应 7.5h， 以60%的产率得到phenyl N-(4-propan-2-yl-2,6,7-trioxa-1λ5-phosphabicyclo[2.2.2]octan-1-ylidene)carbamate
  参考文献：
  名称：

  Lei, Guangqing; Xu, Huatang; Xu, Xuanlang, Phosphorus, Sulfur and Silicon and the Related Elements, 1992, vol. 66, # 1.4, p. 101 - 106

  摘要：

  DOI：

文献信息

• Hydroformylation process
  申请人：DAVY McKEE (LONDON) LIMITED

  公开号：EP0096986A2

  公开（公告）日：1983-12-28

  A continuous process for the production an aldehyde by hydroformylation of an optionally substituted alpha-olefin comprises: providing a hydroformylation zone containing a charge of a liquid reaction medium having dissolved therein a complex rhodium hydroformylation catalyst comprising rhodium in complex combination with carbon monoxide and with a cyclic phosphite having a bridgehead phosphorus atom linked to three oxygen atoms at least two of which form together with the bridgehead phosphorus atom part of a ring; supplying said alpha-olefin to the hydroformylation zone; maintaining temperature and pressure conditions in the hydroformylation zone conducive to hydroformylation of the alpha-olefin; supplying make-up hydrogen and carbon monoxide to the hydroformylation zone; and recovering from the liquid hydroformylation medium a hydroformylation product comprising at least one aldehyde.

  一种通过对任选取代的α-烯烃进行加氢甲酰化生产醛的连续工艺包括：提供一个加氢甲酰化区，该区含有一定量的液体反应介质，其中溶解有复合铑加氢甲酰化催化剂，该催化剂由铑与一氧化碳和环状亚磷酸酯复合而成，环状亚磷酸酯具有与三个氧原子相连的桥头磷原子，其中至少有两个氧原子与桥头磷原子一起形成环的一部分；向加氢甲酰化区提供所述的α-烯烃；在加氢甲酰化区保持有利于α-烯烃加氢甲酰化的温度和压力条件；向加氢甲酰化区提供补给氢和一氧化碳；从液体加氢甲酰化介质中回收包括至少一种醛的加氢甲酰化产物。
• 2-hydroxymethyl-2-propylpropane-1,3-diol in the synthesis of acetal-like and phosphacyclic lipids
  作者：G. A. Savin

  DOI：10.1134/s1070428007110048

  日期：2007.11

  New acetal-like and phosphacyclic lipids were synthesized on the basis of 2-hydroxymethyl-2-propylpropane-1,3-diol. The initial triol was initially treated with higher aldehydes to obtain the corresponding acetals, which were phosphorylated with chlorobis(diethylamino)phosphine. Intermediate phosphorodiamidites were oxidized (without isolation) with phenyliodane oxide or subjected to sulfurization or selenization. Bicyclic phosphite derived from 2-hydroxymethyl-2-propylpropane-1,3-diol was acylated with hexadecanoyl chloride to give 2-chloro-4-propyl-1,3,2-dioxaphosphinan-4-ylmethyl hexadecanoate, and methanolysis of the latter, followed by sulfurization, afforded 2-methoxy-5-propyl-2-thioxo-1,3,2 lambda(5)-dioxaphosphinan-5-ylmethyl hexadecanoate as a new phosphacyclic lipid.
• US4482749A
  申请人：——

  公开号：US4482749A

  公开（公告）日：1984-11-13
• US4496768A
  申请人：——

  公开号：US4496768A

  公开（公告）日：1985-01-29
• US4567306A
  申请人：——

  公开号：US4567306A

  公开（公告）日：1986-01-28

表征谱图