8-trityloxy-oct-4-en-1-ol | 528840-86-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 8-trityloxy-oct-4-en-1-ol
• 英文别名: 8-(Triphenylmethoxy)oct-4-EN-1-OL；8-trityloxyoct-4-en-1-ol
• CAS: 528840-86-0
• 化学式: C₂₇H₃₀O₂
• 分子量: 386.534
• InChiKey: TYXVYGMLDRYUDZ-UHFFFAOYSA-N

物化性质

• 沸点：
  524.1±50.0 °C(Predicted)
• 密度：
  1.066±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  三苯基氯甲烷 在 三乙胺 、 钌 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 8-trityloxy-oct-4-en-1-ol
  参考文献：
  名称：

  Synthesis of Unsaturated Amino Alcohols through Unexpectedly Selective Ru-Catalyzed Cross-Metathesis Reactions

  摘要：

  A two-step synthesis of N-protected unsaturated amino alcohols is disclosed that relies on an unexpectedly selective cross-metathesis (CM) involving allyl cyanide and pent-4-en-1-ol. The solution concentration and the identity of the Ru complex used are critical to the selectivity and efficiency of CM reactions. The intermediate obtained by CM is converted efficiently to the final desired products through a one-pot nitrile reduction/amine protection procedure.

  DOI：

  10.1021/ol050387g

文献信息

• Synthesis of Unsaturated Amino Alcohols through Unexpectedly Selective Ru-Catalyzed Cross-Metathesis Reactions
  作者：Hamid R. Hoveyda、Martin Vézina

  DOI：10.1021/ol050387g

  日期：2005.5.1

  A two-step synthesis of N-protected unsaturated amino alcohols is disclosed that relies on an unexpectedly selective cross-metathesis (CM) involving allyl cyanide and pent-4-en-1-ol. The solution concentration and the identity of the Ru complex used are critical to the selectivity and efficiency of CM reactions. The intermediate obtained by CM is converted efficiently to the final desired products through a one-pot nitrile reduction/amine protection procedure.