methyl 3-(2-amino-6-chloro-9H-purin-9-yl)-2-(tritylamino)propanoate | 1228040-67-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: methyl 3-(2-amino-6-chloro-9H-purin-9-yl)-2-(tritylamino)propanoate
• 英文别名: methyl (2S)-3-(2-amino-6-chloropurin-9-yl)-2-(tritylamino)propanoate
• CAS: 1228040-67-2
• 化学式: C₂₈H₂₅ClN₆O₂
• 分子量: 512.999
• InChiKey: CZDXVNHVVSPKKT-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N-三苯甲基-L-丝氨酸甲酯 、 2-氨基-6-氯嘌呤 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以51%的产率得到methyl 3-(2-amino-6-chloro-9H-purin-9-yl)-2-(tritylamino)propanoate
  参考文献：
  名称：

  Synthesis of Acyclic Nucleosides with a Chiral Amino Side Chain by the Mitsunobu Coupling Reaction

  摘要：

  A novel and efficient synthetic method has been developed Oar the preparation of chiral acyclic nucleosides with a chiral amino side chain by Mitsunobu reaction between nucleoside bases and protected L-serine. This method suggests a potentially more efficient and complementary process to acquire chiral acyclic nucleosides.

  DOI：

  10.1021/jo100397a

文献信息

• Synthesis of Acyclic Nucleosides with a Chiral Amino Side Chain by the Mitsunobu Coupling Reaction
  作者：Hai-Ming Guo、Yan-Yan Wu、Hong-Ying Niu、Dong-Chao Wang、Gui-Rong Qu

  DOI：10.1021/jo100397a

  日期：2010.6.4

  A novel and efficient synthetic method has been developed Oar the preparation of chiral acyclic nucleosides with a chiral amino side chain by Mitsunobu reaction between nucleoside bases and protected L-serine. This method suggests a potentially more efficient and complementary process to acquire chiral acyclic nucleosides.