1,3,5-Triazine-2,4,6-tricarboximidamide | 847399-13-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 1,3,5-Triazine-2,4,6-tricarboximidamide
• CAS: 847399-13-7
• 化学式: C₆H₉N₉
• 分子量: 207.2
• InChiKey: YQMFRZWQVJBHCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  188
• 氢给体数：
  6
• 氢受体数：
  6

文献信息

• MODIFICATION OF DOUBLE-STRANDED RIBONUCLEIC ACID MOLECULES
  申请人：Quay Steven C.

  公开号：US20090018097A1

  公开（公告）日：2009-01-15

  A double-stranded RNA (dsRNA) molecule comprising between about 15 base pairs and about 40 base pairs, wherein at least one ribonucleotide of the dsRNA is a 5′-methyl-pyrimidine and/or at least one 2′-O-methyl ribonucleotide, and a method of improving ribonuclease stability, reducing off-target effects of a double stranded siRNA molecule, or of reducing interferon responsiveness of a double stranded siRNA molecule using such dsRNA.

  一种含有大约15个碱基对至约40个碱基对的双链RNA（dsRNA）分子，其中dsRNA的至少一个核糖核苷酸是5'-甲基嘧啶和/或至少一个2'-O-甲基核糖核苷酸，并且使用这种dsRNA来改善核糖核酸酶稳定性、减少双链siRNA分子的非特异性效应或减少双链siRNA分子的干扰素响应的方法。
• NANOPARTICLES FOR DELIVERY OF NUCLEIC ACIDS AND STABLE DOUBLE-STRANDED RNA
  申请人：Quay C. Steven

  公开号：US20070155658A1

  公开（公告）日：2007-07-05

  Nanoparticles of double-stranded nucleic acid complexed about a complexing agent such as the melamine derivatives of formulae I and II, preferably forming a trimeric nucleic acid complex. In alternative embodiments, polyarginine or a polymer of Gln and Asn further complexed with the double-stranded nucleic acid complex. In a preferred embodiment, the ds nucleic acid is a double stranded RNA having 15 to 30 base pairs suitable for RNA interference. In another aspect of the invention, a ds RNA is produced in which all of the uridines are changed to 5-methyluridine. Preferably, the resultant ds RNAs have 15 to about 30 base pairs and are suitable for RNA interference.
• [EN] MODIFICATION OF DOUBLE-STRANDED RIBONUCLEIC ACID MOLECULES<br/>[FR] MODIFICATION DE MOLECULES D'ACIDE RIBONUCLEIQUE BICATENAIRE
  申请人：NASTECH PHARM CO

  公开号：WO2007030167A1

  公开（公告）日：2007-03-15

  [EN] A double-stranded RNA (dsRNA) molecule comprising between about 15 base pairs and about 40 base pairs, wherein at least one ribonucleotide of the dsRNA is a 5'-methyl-pyrimidine and/or at least one 2'-O-methyl ribonucleotide, and a method of improving ribonuclease stability, reducing off-target effects of a double stranded siRNA molecule, or of reducing interferon responsiveness of a double stranded siRNA molecule using such dsRNA.
  [FR] L'invention a trait à une molécule d'ARN bicaténaire comprenant entre environ 15 paires de bases et environ 40 paires de bases, au moins un ribonucléotide de l'ARN bicaténaire étant une 5'-méthyl-pyrimidine et/ou au moins un 2'-O-méthyl ribonucléotide; et à un procédé permettant d'améliorer la stabilité d'une ribonucléase, de réduire les effets non ciblés d'une molécule d'ARNsi bicaténaire, ou de réduire la sensibilité aux interférons d'une molécule d'ARNsi bicaténaire à l'aide d'un tel ARN bicaténaire.