6,7-Difluorobenzo[d]isoxazol-3-amine | 268734-40-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并异恶唑
• 英文名称: 6,7-Difluorobenzo[d]isoxazol-3-amine
• 英文别名: 6,7-difluoro-1,2-benzoxazol-3-amine
• CAS: 268734-40-3
• 化学式: C₇H₄F₂N₂O
• 分子量: 170.12
• InChiKey: UKRBIPMDAGJHSQ-UHFFFAOYSA-N

物化性质

• 沸点：
  321.1±37.0 °C(Predicted)
• 密度：
  1.542±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• AMINOBENZISOXAZOLE COMPOUNDS AND LIBRARIES THEREOF
  申请人：ELI LILLY AND COMPANY

  公开号：EP1135023A1

  公开（公告）日：2001-09-26
• EP1135023A4
  申请人：——

  公开号：EP1135023A4

  公开（公告）日：2003-03-05
• [EN] AMINOBENZISOXAZOLE COMPOUNDS AND LIBRARIES THEREOF<br/>[FR] COMPOSES AMINOBENZISOXAZOLE ET BANQUES CONTENANT DE TELS COMPOSES
  申请人：LILLY CO ELI

  公开号：WO2000027199A1

  公开（公告）日：2000-05-18

  This invention is directed to aminobenzisoxazole compounds, methods for producing such compounds and libraries thereof. This library is useful for screening the biological activity of the aminobenzisoxazole compounds.
• [EN] ARYLOXIME LINKERS IN THE SOLID-PHASE SYNTHESIS OF 3-AMINOBENZISOXAZOLES<br/>[FR] LIEURS D'ARYLOXIME DANS LA SYNTHESE DE LA PHASE SOLIDE DE 3-AMINOBENZISOXAZOLES
  申请人：LILLY CO ELI

  公开号：WO2000027627A1

  公开（公告）日：2000-05-18

  In its first aspect, the invention is directed to a solid support mediated method for the synthesis of diverse polycyclic heterocycles according to general formula (V). A second aspect of the invention is directed to a solid support bound intermediate compound that optionally can be derivatized before a cyclization and displacement procedure provides a product. The intermediate is preferably stable to a wide range of chemical conditions thus allowing, if desired, for the chemical derivatization of the intermediate. A third aspect of the invention is directed to a library of polycyclic heterocycle compounds where said library contains a plurality of diverse library compounds of general formula (V). A fourth aspect of the invention is directed to a method for the synthesis of a library of diverse polycyclic heterocycles by the general method described. A fifth aspect of the invention is directed to an assay kit for the identification of lead compounds of the library described therein.