(1-Hex-5-enoxy-2-methylprop-1-enoxy)-trimethylsilane | 1235998-24-9

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (1-Hex-5-enoxy-2-methylprop-1-enoxy)-trimethylsilane
• CAS: 1235998-24-9
• 化学式: C₁₃H₂₆O₂Si
• 分子量: 242.434
• InChiKey: BETHLFRLKUGJPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.46
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (S)-2-(2-oxoacetylamino)-propionic acid methyl ester 、 (1-Hex-5-enoxy-2-methylprop-1-enoxy)-trimethylsilane 以 水 为溶剂， 反应 24.0h， 以45%的产率得到3-hydroxy-N-((S)-1-methoxycarbonylethyl)-2,2-dimethylsuccinamidic acid hex-5-enyl ester
  参考文献：
  名称：

  Functionalization of Peptides and Proteins by Mukaiyama Aldol Reaction

  摘要：

  The scope of the catalyst-free water-based Mukaiyama aldol reaction was explored through its application to the site-selective functionalization of N-terminal aldehydes of peptides and proteins. Various functional groups were introduced under mild and environmentally friendly conditions, with the first demonstration of aldol C-C bond formation in protein labeling studies. The efficiency and speed achieved in protein labeling can be of special interest in chemical biology studies.

  DOI：

  10.1021/ja102733a

文献信息

• Functionalization of Peptides and Proteins by Mukaiyama Aldol Reaction
  作者：Jenefer Alam、Thomas H. Keller、Teck-Peng Loh

  DOI：10.1021/ja102733a

  日期：2010.7.21

  The scope of the catalyst-free water-based Mukaiyama aldol reaction was explored through its application to the site-selective functionalization of N-terminal aldehydes of peptides and proteins. Various functional groups were introduced under mild and environmentally friendly conditions, with the first demonstration of aldol C-C bond formation in protein labeling studies. The efficiency and speed achieved in protein labeling can be of special interest in chemical biology studies.