(1R,3R,4R,7S)-7-[2-cyanoethoxy(diisopropylamino)phosphinoxy]-1-[1-(S)-(4,4'-dimethoxytrityloxy)ethyl]-3-(4-N-benzoyl-cytosin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane | 956485-02-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (1R,3R,4R,7S)-7-[2-cyanoethoxy(diisopropylamino)phosphinoxy]-1-[1-(S)-(4,4'-dimethoxytrityloxy)ethyl]-3-(4-N-benzoyl-cytosin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane
• 英文别名: N-[1-[(1R,3R,4R,7S)-1-[(1S)-1-[bis(4-methoxyphenyl)-phenylmethoxy]ethyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-2-oxopyrimidin-4-yl]benzamide
• CAS: 956485-02-2
• 化学式: C₄₈H₅₄N₅O₉P
• 分子量: 875.959
• InChiKey: DBERMVFYCCZZRG-CKNQDWCFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  63
• 可旋转键数：
  19
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  153
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• 5'-MODIFIED BICYCLIC NUCLEIC ACID ANALOGS
  申请人：Isis Pharmaceuticals, Inc.

  公开号：EP2066684B1

  公开（公告）日：2012-07-18
• BIS-MODIFIED BICYCLIC NUCLEIC ACID ANALOGS
  申请人：Isis Pharmaceuticals, Inc.

  公开号：EP2376516B1

  公开（公告）日：2013-04-17
• 5'-SUBSTITUTED BICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM
  申请人：Migawa Michael T.

  公开号：US20130041144A1

  公开（公告）日：2013-02-14

  Provided herein are novel 5′-(S)—CH 3 substituted bicyclic nucleosides, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, the furanose ring of each of the novel 5′-(S)—CH 3 substituted bicyclic nucleosides includes a 2′ to 4′ bridging group. The 5′-(S)—CH 3 substituted bicyclic nucleosides are expected to be useful for enhancing one or more properties of the oligomeric compounds they are incorporated into such as for example increasing the binding affinity. In certain embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
• US7547684B2
  申请人：——

  公开号：US7547684B2

  公开（公告）日：2009-06-16
• US7666854B2
  申请人：——

  公开号：US7666854B2

  公开（公告）日：2010-02-23