1-methyl-3-(5-m-tolylnicotinoyl)pyrrolidin-2-one | 1434288-77-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-methyl-3-(5-m-tolylnicotinoyl)pyrrolidin-2-one
• 英文别名: 1-Methyl-3-[5-(3-methylphenyl)pyridine-3-carbonyl]pyrrolidin-2-one
• CAS: 1434288-77-3
• 化学式: C₁₈H₁₈N₂O₂
• 分子量: 294.353
• InChiKey: QNCLOURKADZPQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  50.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Novel nicotine derivatives
  申请人：Gandhi Paresh T.

  公开号：US20130123106A1

  公开（公告）日：2013-05-16

  Described are novel nicotine derivatives represented by general formulas (I) and (III), and salts thereof, and herbicide & pharmaceutical compositions containing the same as the active ingredient. The compound and salts thereof can control annual or perennial weed growing on the land where various crops such as rice plant, wheat, cotton and corn grow for a wide period ranging from the pre-emergence to growth in a remarkably small dose. The compounds and salts thereof can be useful as an anti-microbial and anti-fungal agents and also for the treatment of blood pressure, skeletal muscle, attention deficit disorder, mental disorders, schizophrenia, Alzheimer disease, Parkinson's disease and depression. Also described is the preparation of the nicotine derivatives having formula (I) and (III).

  本文描述了一种新型尼古丁衍生物，其通式为（I）和（III），以及它们的盐，以及包含它们作为活性成分的除草剂和药物组合物。该化合物及其盐可以在极小的剂量下控制年生或多年生杂草在各种作物如水稻、小麦、棉花和玉米生长的土地上，时间范围从发芽前到生长期。该化合物及其盐可用作抗菌和抗真菌剂，也可用于治疗血压、骨骼肌、注意力缺陷障碍、精神障碍、精神分裂症、阿尔茨海默病、帕金森病和抑郁症。本文还描述了具有式（I）和（III）的尼古丁衍生物的制备方法。
• US20140256773A1
  申请人：——

  公开号：US20140256773A1

  公开（公告）日：2014-09-11
• US8754228B2
  申请人：——

  公开号：US8754228B2

  公开（公告）日：2014-06-17
• US8835640B1
  申请人：——

  公开号：US8835640B1

  公开（公告）日：2014-09-16
• [EN] NOVEL NICOTINE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS DE LA NICOTINE
  申请人：GANDHI PARESH

  公开号：WO2013072829A1

  公开（公告）日：2013-05-23

  Described are novel nicotine derivatives represented by general formulas (I) and (III), and salts thereof, and herbicide & pharmaceutical compositionscontaining the same as the active ingredient. The compound and salts thereof can control annual or perennial weed growing on the land where various crops such as rice plant, wheat, cotton and corn grow for a wide period ranging from the pre-emergence to growth in a remarkably small dose. The compounds and salts thereof can be useful as an anti-microbial and anti-fungal agents and also for the treatment of blood pressure, skeletal muscle, attention deficit disorder, mental disorders, schizophrenia, Alzheimer disease, Parkinson's disease and depression. Also described is the preparation of the nicotine derivatives having formula (I) and (III).