| 216692-02-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• CAS: 216692-02-3
• 化学式: C₄₈H₅₆FN₄O₁₁PSi
• 分子量: 943.051
• InChiKey: KMFARFTWEFKCSH-DLBBVOJMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.02
• 重原子数：
  66.0
• 可旋转键数：
  20.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  164.96
• 氢给体数：
  1.0
• 氢受体数：
  14.0

反应信息

• 作为反应物：
  描述：

  生成
  参考文献：
  名称：

  A novel solid support for synthesis of 2′,3′-cyclic phosphate terminated oligonucleotides

  摘要：

  Michaelis-Arbusov chemistry was used to prepare O,S-dialkyl 3 '-O-nucleosidyl phosphorothiolate triesters in solution and attached to CPG. The support-bound nucleoside was utilised in the synthesis of a pentaribonucleotide that was fully deprotected on the support. Subsequent treatment with a buffered solution of iodine cleaved the RNA from the CPG with concomitant formation of a terminal 2 ',3 '-cyclic phosphate. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01734-1
• 作为产物：
  描述：

  3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]oxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile 在 四氮唑 、 水 作用下， 以 氘代氯仿 、 乙腈 为溶剂， 反应 2.25h， 生成
  参考文献：
  名称：

  A novel solid support for synthesis of 2′,3′-cyclic phosphate terminated oligonucleotides

  摘要：

  Michaelis-Arbusov chemistry was used to prepare O,S-dialkyl 3 '-O-nucleosidyl phosphorothiolate triesters in solution and attached to CPG. The support-bound nucleoside was utilised in the synthesis of a pentaribonucleotide that was fully deprotected on the support. Subsequent treatment with a buffered solution of iodine cleaved the RNA from the CPG with concomitant formation of a terminal 2 ',3 '-cyclic phosphate. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01734-1