2-N-(2-methoxyethyl)-4-N-phenyl-6-{5-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-1,2,4-oxadiazol-3-yl}-1,3,5-triazine-2,4-diamine | 1366659-49-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 2-N-(2-methoxyethyl)-4-N-phenyl-6-{5-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-1,2,4-oxadiazol-3-yl}-1,3,5-triazine-2,4-diamine
• 英文别名: 4-N-(2-methoxyethyl)-2-N-phenyl-6-[5-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-1,2,4-oxadiazol-3-yl]-1,3,5-triazine-2,4-diamine
• CAS: 1366659-49-5
• 化学式: C₂₁H₁₉F₃N₈O₃
• 分子量: 488.429
• InChiKey: JYRRYMWOHRTCIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  133
• 氢给体数：
  2
• 氢受体数：
  14

文献信息

• [EN] TRIAZINE-OXADIAZOLES<br/>[FR] TRIAZINE-OXADIAZOLES
  申请人：NOVARTIS AG

  公开号：WO2012035023A1

  公开（公告）日：2012-03-22

  The invention relates to new derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of chronic pain.

  这项发明涉及公式（I）的新衍生物，其中取代基如规范中所定义；制备这种衍生物的方法；包括这种衍生物的药物组合物；将这种衍生物用作药物；将这种衍生物用于治疗慢性疼痛。
• THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
  申请人：Agios Pharmaceuticals, Inc.

  公开号：US20170044139A1

  公开（公告）日：2017-02-16

  Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.

  提供了用于治疗癌症的化合物，并且包括将所述化合物用于治疗需要的受试者的治疗方法。
• THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE
  申请人：Agios Pharmaceuticals, Inc.

  公开号：US20160318903A1

  公开（公告）日：2016-11-03

  Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.

  提供了用于治疗癌症的化合物和治疗癌症的方法，包括向需要治疗的受试者给予此处所描述的化合物。
• Triazine-oxadiazoles
  申请人：BARKER Oliver

  公开号：US20140051676A1

  公开（公告）日：2014-02-20

  The invention relates to new derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of chronic pain.

  该发明涉及公式(I)的新衍生物，其中取代基如规范中所定义；制备这种衍生物的方法；包含这种衍生物的药物组合物；这种衍生物作为药物；这种衍生物用于治疗慢性疼痛。
• Therapeutically active compounds and their methods of use
  申请人：Agios Pharmaceuticals, Inc.

  公开号：US10294215B2

  公开（公告）日：2019-05-21

  Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.

  本发明提供了用于治疗癌症的化合物以及治疗癌症的方法，其中包括向有需要的受试者施用本文所述的化合物。