1,6-anhydro-3-butyl-3,4-dideoxy-β-D-threo-hex-3-enopyranose | 155618-28-3

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 1,6-anhydro-3-butyl-3,4-dideoxy-β-D-threo-hex-3-enopyranose
• 英文别名: (1S,4S,5R)-3-butyl-6,8-dioxabicyclo[3.2.1]oct-2-en-4-ol
• CAS: 155618-28-3
• 化学式: C₁₀H₁₆O₃
• 分子量: 184.235
• InChiKey: WSWZSDULMCEBLL-LPEHRKFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Immuno-suppressing enepyranose derivatives
  申请人：ISHIHARA SANGYO KAISHA, LTD.

  公开号：EP0560055A1

  公开（公告）日：1993-09-15

  An immuno-suppressive agent containing, as an effective component, an enopyranose derivative of the following formula (I) or its salt: wherein R1 is a hydrogen atom, alkyl which may be substituted, alkenyl, alkynyl, -OSO2R7, a halogen atom, -OCOR7, -NHCOR8, alkoxy, phenyl which may be substituted or a saccharose residue, R2 is a hydrogen atom or alkyl, R3 is a hydrogen atom or a halogen atom, R4 is a hydrogen atom, -COR9, silyl which may be substituted or alkyl which may be substituted, one of R5 and R6 is hydroxyl, alkoxy which may be substituted, a saccharose residue, cycloalkyloxy which may be substituted or -OCOR10 and the other is a hydrogen atom or alkyl which may be substituted, or R4 and R5 together form a single bond, while R6 is a hydrogen atom or alkyl which may be substituted, each of R7, R9 and R10 is alkyl or phenyl which may be substituted, R8 is alkyl, phenyl which may be substituted or benzyloxy, X is a hydrogen atom, alkyl which may be substituted, alkenyl which may be substituted, alkynyl which may be substituted, cycloalkyl which may be substituted, phenyl which may be substituted, pyridyl which may be substituted, furanyl which may be substituted, thienyl which may be substituted, formyl, -COR11, -C(W1)W2R11 or -SO2R11, R11 is a chain hydrocarbon group which may be substituted, a monocyclic hydrocarbon group which may be substituted, a polycyclic hydrocarbon group which may be substituted, a monocyclic heterocycle group which may be substituted, or a polycyclic heterocycle group which may be substituted, W1 is an oxygen atom or a sulfur atom, W2 is an oxygen atom, a sulfur atom or -NH-, Y is a hydrogen atom, alkyl which may be substituted, alkenyl which may be substituted or alkynyl which may be substituted.

  一种含有下式(I)的烯吡喃糖衍生物或其盐作为有效成分的免疫抑制剂： 其中 R1 是氢原子、可被取代的烷基、烯基、炔基、-OSO2R7、卤素原子、-OCOR7、-NHCOR8、烷氧基、可被取代的苯基或糖残基；R2 是氢原子或烷基；R3 是氢原子或卤素原子；R4 是氢原子、-COR9、可被取代的硅烷基或可被取代的烷基；R5 和 R6 中的一个是羟基、可被取代的烷氧基、糖残基、可被取代的环烷氧基或-OCOR10，另一个是氢原子或可被取代的烷基，或 R4 和 R5 一起形成单键，而 R6 是氢原子或可被取代的烷基，R7、R9 和 R10 各为烷基或可被取代的苯基，R8 是烷基、可被取代的苯基或苄氧基，X 是氢原子、可被取代的烷基，可被取代的烯基，可被取代的炔基，可被取代的环烷基，可被取代的苯基，可被取代的吡啶基，可被取代的呋喃基，可被取代的噻吩基，甲酰基，-COR11，-C(W1)W2R11 或-SO2R11，R11 是可被取代的链烃基，可被取代的单环烃基、W1 是氧原子或硫原子，W2 是氧原子、硫原子或-NH-，Y 是氢原子、可被取代的烷基、可被取代的烯基或可被取代的炔基。
• US5380834A
  申请人：——

  公开号：US5380834A

  公开（公告）日：1995-01-10