5'-O-dimethoxytrityl-5-methyl-2-thiouridine | 182495-95-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5'-O-dimethoxytrityl-5-methyl-2-thiouridine
• 英文别名: 1-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]-5-methyl-2-sulfanylidenepyrimidin-4-one
• CAS: 182495-95-0
• 化学式: C₃₁H₃₂N₂O₇S
• 分子量: 576.67
• InChiKey: KANKSPVIKCJZSM-LTGLEFCMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  142
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• EP1611249A1
  申请人：——

  公开号：EP1611249A1

  公开（公告）日：2006-01-04
• EP1611249A4
  申请人：——

  公开号：EP1611249A4

  公开（公告）日：2006-06-28
• [EN] OLIGORIBONUCLEOTIDES AND RIBONUCLEASES FOR CLEAVING RNA<br/>[FR] OLIGORIBONUCLEOTIDES ET RIBONUCLEASES DE CLIVAGE D'ARN
  申请人：ISIS PHARMACEUTICALS INC

  公开号：WO2004097049A1

  公开（公告）日：2004-11-11

  Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2'-pentoribofuran-osyl nucleosides that activate dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinity to complementary nucleic acid strand as well as substituent groups for increasing nuclease resistance. The oligomeric compounds are useful for diagnostics and other research purposes, for modulat-ing the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to oligonucleotide therapeutics. Also included in the invention are mammalian ribonucleases, i.e., enzymes that degrade RNA, and substrates for such ribonucleases. Such a ribonuclease is referred to herein as a dsRNase, wherein 'ds' indicates the RNase's specificity for certain double-stranded RNA substrates. The artificial substrates for the dsRNases described herein are useful in preparing affinity matrices for purifying mammalian ribonuclease as well as non-degradative RNA-binding proteins.