O-[(R)-3-(acridin-9-ylamino)-1-(4,4'-dimethoxytrityl)oxypropane-2-yl]-N,N-diisopropylamino-2-cyanoethoxyphosphoramidite | 1029683-07-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: O-[(R)-3-(acridin-9-ylamino)-1-(4,4'-dimethoxytrityl)oxypropane-2-yl]-N,N-diisopropylamino-2-cyanoethoxyphosphoramidite
• CAS: 1029683-07-5
• 化学式: C₄₆H₅₁N₄O₅P
• 分子量: 770.908
• InChiKey: VENRCSVAUMYZKD-DXXIRTLYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.49
• 重原子数：
  56.0
• 可旋转键数：
  19.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  98.1
• 氢给体数：
  1.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  O-[(R)-3-(acridin-9-ylamino)-1-(4,4'-dimethoxytrityl)oxypropane-2-yl]-N,N-diisopropylamino-2-cyanoethoxyphosphoramidite 、 4-trityloxybutyric acid 以25%的产率得到
  参考文献：
  名称：

  Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones

  摘要：

  A method for the preparation of oligomers by linking chromophore units is described. Specifically, the synthesis of chromophore units having a protected-hydroxyl group and a phosphoramidite function is described, along with a method to link several units using solid-phase phosphite-triester protocols. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.074
• 作为产物：
  描述：

  (R)-3-(acridin-9-ylamino)-1-(4,4'-dimethoxytrityl)oxypropane-2-ol 、 2-氰乙基N,N-二异丙基氯亚磷酰胺 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 2.0h， 以90%的产率得到O-[(R)-3-(acridin-9-ylamino)-1-(4,4'-dimethoxytrityl)oxypropane-2-yl]-N,N-diisopropylamino-2-cyanoethoxyphosphoramidite
  参考文献：
  名称：

  Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones

  摘要：

  A method for the preparation of oligomers by linking chromophore units is described. Specifically, the synthesis of chromophore units having a protected-hydroxyl group and a phosphoramidite function is described, along with a method to link several units using solid-phase phosphite-triester protocols. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.074