3-羟基-5-甲基苯基苯甲酸酯 | 848130-90-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 中文名称: 3-羟基-5-甲基苯基苯甲酸酯
• 中文别名: 3-羟基-5-甲基苯甲酸甲酯；3-羟基-5-甲苯基安息香酸盐
• 英文名称: 3-hydroxy-5-methylphenyl benzoate
• 英文别名: (3-hydroxy-5-methylphenyl) benzoate
• CAS: 848130-90-5
• 化学式: C₁₄H₁₂O₃
• 分子量: 228.247
• InChiKey: HYLQICWQHBSZQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-羟基-5-甲基苯基苯甲酸酯 在 sodium hydroxide 、 potassium carbonate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 4-(3-hydroxy-5-methylphenoxy)butyronitrile
  参考文献：
  名称：

  Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 1. Initial structure-activity relationships

  摘要：

  This series of reports describes the development of orally active, highly potent, specific antagonists of the peptidoleukotrienes containing a (2-quinolinylmethoxy)phenyl moiety. Described in this first report are the structure-activity relationships that led to a more than a 20-fold improvement of the potency and selectivity of the initial chemical lead (RG 5901). From this series of compounds, RG 7152 (16) was identified and selected for further evaluation in the clinic as an antiasthmatic agent. Compound 16 competitively inhibits [3H]LTD4 binding to membranes from guinea pig lung (Ki = 38 +/- 6 nM) and the spasmogenic activity of LTC4, LTD4, and LTE4 in parenchymal lung strips from guinea pigs. Unlike the original lead (RG 5901), compound 16 does not inhibit 5-lipoxygenase from guinea pig PMNs. Following oral administration to guinea pigs, 16 blocks LTD4-induced dermal permeability (ED50 = 6.9 mg/kg), LTD4-induced bronchoconstriction (ED50 = 1.1 mg/kg), antigen-induced bronchoconstriction (ED50 = 2.5 mg/kg), and anaphylactic-induced mortality (ED50 = 16 mg/kg). These studies on structure-activity relationships indicate that there is a requirement for an acidic function and the presence of the (2-quinolinylmethoxy)phenyl moiety in a specific geometric arrangement.

  DOI：

  10.1021/jm00166a016

文献信息

• Stabilized moisture-curable polymeric compositions
  申请人：Dow Global Technologies LLC

  公开号：US10100181B2

  公开（公告）日：2018-10-16

  Silane-crosslinkable polymeric compositions comprising a polyolefin having hydrolyzable silane groups, an acidic silanol condensation catalyst, and a phenolic antioxidant having at least one ester-containing moiety. Such crosslinkable polymeric compositions can be employed in various articles of manufacture, such as in the wire and cable industry.

  硅烷可交联聚合物组合物包含一种具有可水解硅烷基团的聚烯烃、一种酸性硅烷醇缩合催化剂和一种具有至少一个含酯分子的酚类抗氧化剂。这种可交联聚合物组合物可用于各种制造品，如电线电缆行业。
• STABILIZED MOISTURE-CURABLE POLYMERIC COMPOSITIONS
  申请人：Dow Global Technologies LLC

  公开号：EP3161063A1

  公开（公告）日：2017-05-03
• [EN] STABILIZED MOISTURE-CURABLE POLYMERIC COMPOSITIONS<br/>[FR] COMPOSITIONS POLYMÈRES STABILISÉES DURCISSABLES À L'HUMIDITÉ
  申请人：DOW GLOBAL TECHNOLOGIES LLC

  公开号：WO2015200016A1

  公开（公告）日：2015-12-30

  Silane-crosslinkable polymeric compositions comprising a polyolefin having hydrolyzable silane groups, an acidic silanol condensation catalyst, and a phenolic antioxidant having at least one ester-containing moiety. Such crosslinkable polymeric compositions can be employed in various articles of manufacture, such as in the wire and cable industry.