4-(morpholine-4-yl)-6-(piperidin-1-yl)-1,3,5-triazine-2-carbonitrile | 442660-14-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 4-(morpholine-4-yl)-6-(piperidin-1-yl)-1,3,5-triazine-2-carbonitrile
• 英文别名: 4-Morpholin-4-yl-6-piperidin-1-yl-1,3,5-triazine-2-carbonitrile
• CAS: 442660-14-2
• 化学式: C₁₃H₁₈N₆O
• 分子量: 274.326
• InChiKey: BEGBRSYHRSOITI-UHFFFAOYSA-N

物化性质

• 沸点：
  498.1±55.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  78.2
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4-(morpholine-4-yl)-6-(piperidin-1-yl)-1,3,5-triazine-2-carbonitrile 在 盐酸 作用下， 以65%的产率得到4-Morpholin-4-yl-6-piperidin-1-yl-1,3,5-triazine-2-carboxamide
  参考文献：
  名称：

  三嗪类。7. 1,3,5-三嗪系列单腈的水解和环化

  摘要：

  DOI：

  10.1007/s10593-006-0140-0

文献信息

• [EN] 2-CYANO-1,3,5-TRIAZINE-4,6-DIAMINE DERIVATIVES<br/>[FR] DERIVES 2-CYANO-1,3,5-TRIAZINE-4,6-DIAMINES
  申请人：AKZO NOBEL NV

  公开号：WO2005011703A1

  公开（公告）日：2005-02-10

  The invention relates to the use of a 2-cyano-1,3,5-triazine -4,6-diamine derivative having general formula (I), wherein R1 is (C1-6)alkyl, (C3-8)cycloalkyl, aryl, aryl(C1-4)alkyl, aryloxy(C1-4)alkyl, heteroaryl or heteroaryloxy(C1-4)alkyl; R2 is H or (C1-4)alkyl; or R1 and R2 together with the nitrogen to which they are bound form a 4-8 membered heterocyclic ring, optionally further comprising 1 or more heteroatoms selected from O, S or NR5, which ring may be substituted with (C1-4)alkyl, (C3-8)cycloalkyl, aryl, aryl(C1-4)alkyl or NR6R7,and which ring may be fused to a benzene ring; R3 is (C1-6)alkyl, (C3-8) cycloalkyl (optionally comprising 1 or more heteroatoms selected from O, S or NR8), aryl, aryl(C1-4)alkyl or heteroaryl; R4 is H or (C1-4)alkyl; or R3 and R4 together with the nitrogen to which they are bound form a 4-8 membered heterocyclic ring, optionally further comprising 1 or more heteroatoms selected from O, S or NR9; R5, R8 and R9 are independently H, (C1-4)alkyl, (C3-8) cycloalkyl, aryl or aryl(C1-4)alkyl; R6 and R7 are independently H or (C1-4)alkyl; or R6 and R7 form together with the nitrogen to which they are bound a 4-8 membered heterocyclic ring; or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for the treatment of osteoporosis and atherosclerosis.

  该发明涉及使用具有通式（I）的2-氰基-1,3,5-三嗪-4,6-二胺衍生物，其中R1为（C1-6）烷基，（C3-8）环烷基，芳基，芳基（C1-4）烷基，芳氧基（C1-4）烷基，杂芳基或杂芳氧基（C1-4）烷基；R2为H或（C1-4）烷基；或R1和R2与它们结合的氮一起形成一个4-8元杂环，可进一步包括1个或多个来自O、S或NR5的杂原子，该环可能被（C1-4）烷基，（C3-8）环烷基，芳基，芳基（C1-4）烷基或NR6R7取代，并且该环可能与苯环融合；R3为（C1-6）烷基，（C3-8）环烷基（可包括来自O、S或NR8的1个或多个杂原子），芳基，芳基（C1-4）烷基或杂芳基；R4为H或（C1-4）烷基；或R3和R4与它们结合的氮一起形成一个4-8元杂环，可进一步包括1个或多个来自O、S或NR9的杂原子；R5、R8和R9独立地为H，（C1-4）烷基，（C3-8）环烷基，芳基或芳基（C1-4）烷基；R6和R7独立地为H或（C1-4）烷基；或R6和R7与它们结合的氮一起形成一个4-8元杂环；或其药学上可接受的盐，用于制备治疗骨质疏松症和动脉粥样硬化的药物。
• [EN] METHOD OF CROSSLINKING INTRINSICALLY CONDUCTIVE POLYMERS OR INTRINSICALLY CONDUCTIVE POLYMER PRECURSORS AND THE ARTICLES OBTAINED THEREFROM<br/>[FR] PROCEDE DE RETICULATION DE POLYMERES INTRINSEQUEMENT CONDUCTEURS OU DE PRECURSEURS DE POLYMERES INTRINSEQUEMENT CONDUCTEURS, ET ARTICLES REALISES A PARTIR DE CES PRODUITS
  申请人：UNIV CONNECTICUT

  公开号：WO2005014693A1

  公开（公告）日：2005-02-17

  A method of manufacturing an intrinsically conductive polymer crosslinking at least a portion of an intrinsically conductive polymer precursor in the solid state, the swollen state, or combinations comprising at least one of the foregoing states, wherein the swollen state is characterized as being one wherein the intrinsically conductive polymer precursor increases in volume upon exposure to a solvent without completely dissolving in the solvent. In another embodiment, a method of manufacturing a pattern comprises casting a film of an intrinsically conductive polymer precursor on a substrate; and crosslinking at least a portion of the film by oxidation, wherein the crosslinking occurs in the solid state, the swollen state or combinations comprising at least one of the foregoing states.