Methyl-di-O-methylbarbatat | 58062-15-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: Methyl-di-O-methylbarbatat
• 英文别名: 4-(2,4-dimethoxy-3,6-dimethyl-benzoyloxy)-2-methoxy-3,6-dimethyl-benzoic acid methyl ester；4-(2,4-Dimethoxy-3,6-dimethyl-benzoyloxy)-2-methoxy-3,6-dimethyl-benzoesaeure-methylester
• CAS: 58062-15-0
• 化学式: C₂₂H₂₆O₇
• 分子量: 402.444
• InChiKey: AYUPIVZOHNUFJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.95
• 重原子数：
  29.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  80.29
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  重氮甲烷 、 alkaline earth salt of/the/ methylsulfuric acid 生成 Methyl-di-O-methylbarbatat
  参考文献：
  名称：

  In the arms of morpheus: the development of morphine for postoperative pain relief

  摘要：

  Purpose: To analyse the historical development of morphine for postoperative analgesia and how this development was shaped by the evolution of anesthetic techniques.Methods: After a systematic review of the literature, information was gathered from primary sources.Principal Findings: in ancient medicine, some plant derivatives were used to alleviate pain including: alcohol, cannabis, mandrake, and opium. Over the past two centuries, opium and its derivatives have become the most widely used analgesics for severe pain. Before the development of general anesthesia, surgery was only performed out of extreme necessity. It is probable that an analgesic such as opium would have been given following surgery although its use may not have been recorded. The first description of postoperative opium was by James Moore in 1784, Morphine was isolated from opium by Friedrich Serturner in 1805. However, it was not until the development of the hypodermic needle and syringe nearly 50 yr later that the use of morphine became widespread. Over the last century, various delivery systems for morphine have been developed including sub-arachanoid and epidural injection, and more recently patient-controlled intravenous, epidural and intranasal analgesia. In addition, many new opioids have been synthesized.Conclusion: Since its isolation from opium almost 200 yr ago, morphine remains the most widely used analgesic and the standard against which all new opioids for postoperative pain relief are compared.

  DOI：

  10.1007/bf03020955

文献信息

• Asahina; Fuzikawa, Chemische Berichte, 1932, vol. 65, p. 175,1668
  作者：Asahina、Fuzikawa

  DOI：——

  日期：——