5-(5-bromopyrimidin-2-yl)-4H-1,2,4-triazole-3-thiol | 1516947-99-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 5-(5-bromopyrimidin-2-yl)-4H-1,2,4-triazole-3-thiol
• 英文别名: 5-(5-bromopyrimidin-2-yl)-1,2-dihydro-1,2,4-triazole-3-thione
• CAS: 1516947-99-1
• 化学式: C₆H₄BrN₅S
• 分子量: 258.101
• InChiKey: MQWANWBSQIXNRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• AROMATIC HETEROCYCLIC COMPOUND
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP2862856A1

  公开（公告）日：2015-04-22

  The compound represented by the general formula: wherein ring A is benzene which may be substituted and the like; ring B is benzene which may be substituted and the like; X is a single bond and the like; Y is alkyl which may be substituted and the like; Z is CR1 or nitrogen atom; R1 is hydrogen and the like; R2 is alkyl which may be substituted and the like or a pharmaceutically acceptable salt thereof is useful as a prevention/treatment agent of obesity, diabetes, and the like.

  由通式表示的化合物：其中环 A 是苯，可被取代等；环 B 是苯，可被取代等；X 是单键等；Y 是烷基，可被取代等；Z 是 CR1 或氮原子；R1 是氢等；R2 是烷基，可被取代等或其药学上可接受的盐，可用作肥胖症、糖尿病等的预防/治疗剂。
• Aromatic heterocyclic compound
  申请人：MITSUBISHI TANABE PHARMA CORPORATION

  公开号：US10308636B2

  公开（公告）日：2019-06-04

  The compound represented by the general formula: wherein ring A is benzene which may be substituted and the like; ring B is benzene which may be substituted and the like; X is a single bond and the like; Y is alkyl which may be substituted and the like; Z is CR1 or nitrogen atom; R1 is hydrogen and the like; R2 is alkyl which may be substituted and the like or a pharmaceutically acceptable salt thereof is useful as a prevention/treatment agent of obesity, diabetes, and the like.

  由通式表示的化合物：其中环 A 是苯，可被取代等；环 B 是苯，可被取代等；X 是单键等；Y 是烷基，可被取代等；Z 是 CR1 或氮原子；R1 是氢等；R2 是烷基，可被取代等或其药学上可接受的盐，可用作肥胖症、糖尿病等的预防/治疗剂。
• IMIDAZOLE AND TRIAZOLE COMPOUNDS AS DGAT-1 INHIBITORS
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP2862856B1

  公开（公告）日：2018-08-01
• US9546155B2
  申请人：——

  公开号：US9546155B2

  公开（公告）日：2017-01-17