tetramethyldisiloxane | 109799-70-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: tetramethyldisiloxane
• 英文别名: TMDSO；Tetramethyl disiloxane；trimethyl(methylsilyloxy)silane
• CAS: 109799-70-4
• 化学式: C₄H₁₄OSi₂
• 分子量: 134.326
• InChiKey: UHUUYVZLXJHWDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.97
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,5-已二烯 、 tetramethyldisiloxane 在 氯铂酸 作用下， 80.0 ℃ 、53.32 kPa 条件下， 反应 3.5h， 以3 mm Hg, 178 g of di(5-hexenyl)tetramethyldisiloxane were obtained的产率得到Di(5-hexenyl)tetramethyldisiloxane
  参考文献：
  名称：

  Method for manufacturing an alkenyl group-containing organopolysiloxane

  摘要：

  本发明的方法利用碱催化剂在氧气存在且无二氧化碳存在的情况下，制造含有烯基基团的有机聚硅氧烷。该共聚物在25°C下的粘度至少为500 cst，可以高效制造且无凝胶现象。在该方法中，将由平均式R1aSiO(4-a)/2表示的含有单价碳氢基且不含有烯烃不饱和度的有机聚硅氧烷与由平均式R2bR3cSiO(4-b-c)/2表示的含有4-8个碳原子烯基基团的有机聚硅氧烷进行共聚。

  公开号：

  US04980439A1

文献信息

• Tricyclic DNA gyrase inhibitors
  申请人：Hoffmann-La Roche Inc.

  公开号：US05594135A1

  公开（公告）日：1997-01-14

  The present invention relates to a compound of the formula ##STR1## wherein X.sup.1, R.sup.1, R.sup.2, OP, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.0 are as described herein, and their pharmaceutically acceptable salts thereof carrying an acidic and/or basic substituent. The compound of formula I as well as their pharmaceutically acceptable salts inhibit DNA gyrase activity in bacteria and possess antibiotic, especially antibacterial activity against microorganisms and can be used in the control or prevention of infectious diseases.

  本发明涉及一种化合物，其化学式为##STR1##其中X.sup.1，R.sup.1，R.sup.2，OP，R.sup.3，R.sup.4，R.sup.5，R.sup.6和R.sup.0如本说明所述，并且它们的药学上可接受的酸性和/或碱性取代物质的盐。式I化合物及其药学上可接受的盐抑制细菌中的DNA酶活性，并具有抗生素，特别是抗微生物活性，可用于控制或预防传染病。
• Process for preparing organosiloxanes
  申请人：Wacker-Chemie GmbH

  公开号：US05011962A1

  公开（公告）日：1991-04-30

  Organosiloxanes (1) of the general formula R.sup.1.sub.4-n Si(OSiR.sub.3).sub.n, in which R is the same or different and represents a hydrogen atom or a monovalent hydrocarbon radical having from 1 to 18 carbon atom(s) per radical or a substituted monovalent hydrocarbon radical having from 1 to 18 carbon atom(s) per radical, R.sup.1 represents R or a chlorine atom, and n is 3 or 4, are prepared by reacting organodisiloxanes (2) of the general formula (R.sub.3 Si).sub.2 O, with chlorosilanes (3) of the general formula R.sub.4-n SiCl.sub.n, in which R and n are the same as above, in the presence of phosphonitrile chlorides (4) and cocatalysts (5), in which the cocatalysts (5) are used concomitantly with the phosphonitrile chlorides (4) and are selected from the group consisting of amides of the general formula X--C(O)--R.sup.2, in which R.sup.2 is the same or different and represents a hydrogen atom or a monovalent hydrocarbon radical having from 1 to 8 carbon atom(s) per radical or a substituted monovalent hydrocarbon radical having from 1 to 8 carbon atom(s) per radical, and X reresents a radical of the formula R.sup.2.sub.2 N- or ##STR1## where R.sup.2 is the same as above, R.sup.3 represents a divalent hydrocarbon radical having from 5 to 7 carbon atoms per radical, urea or urea derivatives of the general formula X--C(O)--X, where X is the same as above and cyanuric acid.

  通式为R.sup.1.sub.4-n Si(OSiR.sub.3).sub.n的有机硅氧烷(1)，其中R相同或不同，代表氢原子或每个基团具有1至18个碳原子的单价碳氢基团或每个基团具有1至18个碳原子的取代的单价碳氢基团，R.sup.1代表R或氯原子，n为3或4，通过在磷氮氯化物(4)和共催化剂(5)的存在下，将通式为(R.sub.3 Si).sub.2 O的有机二硅氧烷(2)与通式为R.sub.4-n SiCl.sub.n的氯硅烷(3)反应制备而成。其中，共催化剂(5)与磷氮氯化物(4)同时使用，并从以下群组中选择：通式为X--C(O)--R.sup.2的酰胺，其中R.sup.2相同或不同，代表每个基团具有1至8个碳原子的单价碳氢基团或每个基团具有1至8个碳原子的取代的单价碳氢基团，X代表通式为R.sup.2.sub.2 N-或##STR1##的基团，其中R.sup.2与上述相同，R.sup.3代表每个基团具有5至7个碳原子的双价碳氢基团，或通式为X--C(O)--X的脲或脲衍生物，其中X与上述相同，并且是氰尿酸。
• Mono- and bicyclic DNA gyrase inhibitors
  申请人：Hoffmann-La Roche Inc.

  公开号：US05665746A1

  公开（公告）日：1997-09-09

  The present invention relates to a compound of the formula ##STR1## wherein X.sup.1, R.sup.1, R.sup.2, OP, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.0 are as described herein, and their pharmaceutically acceptable salts thereof carrying an acidic andr basic substituent. The compound of formula I as well as their pharmaceutically acceptable salts inhibit DNA gyrase activity in bacteria and possess antibiotic, especially antibacterial activity against microorganisms and can be used in the control or prevention of infectious diseases.

  本发明涉及一种化合物，其化学式为##STR1##其中X.sup.1，R.sup.1，R.sup.2，OP，R.sup.3，R.sup.4，R.sup.5，R.sup.6和R.sup.0如本文所述，并且其药学上可接受的酸性和碱性取代物的盐。化合物I及其药学上可接受的盐能够抑制细菌中的DNA酶活性，并具有抗生素，特别是抗菌活性，可用于控制或预防传染病。
• Method for the preparation of pure carboxyethyl germanium sesquioxide
  申请人：——

  公开号：US05703259A1

  公开（公告）日：1997-12-30

  A synthetic method for generating pure carboxyethyl germanium sesquioxide in the absence of toxic impurities. In the method germanium dioxide and metallic germanium are not used as starting materials. The method involves steps which ensure (a) absence of any residual germanium tetrachloride to ensure none is available to form germanium dioxide, (b) removal of any germanium dioxide, (c) removal of any germanium tetrachloride later produced from any germanium dioxide and (d) final removal of any germanium dioxide. In an alternative method, intermediate TPA is prepared by direct precipitation from a concentrated solution with a halogenated solvent preferably dichloromethane when poured into a non-polar alkyl solvent preferably hexane at ambient temperature and then converted to carboxyethyl germanium sesquioxide.

  一种合成纯的羧基乙基二氧化锗的方法，在没有有毒杂质的情况下。该方法不使用二氧化锗和金属锗作为起始材料。该方法包括以下步骤，以确保(a)没有任何残留的四氯化锗，以确保没有可用的四氧化锗，(b)去除任何二氧化锗，(c)去除任何后来从任何二氧化锗产生的四氯化锗，以及(d)最终去除任何二氧化锗。在另一种方法中，通过在浓缩溶液中使用卤代溶剂（最好是二氯甲烷）直接沉淀中间体TPA，然后在室温下将其倒入非极性烷基溶剂（最好是正己烷）中，并转化为羧基乙基二氧化锗。
• EXTREME ENVIRONMENT SURFACTANT COMPOSITIONS COMPRISING HYDROLYSIS RESISTANT ORGANOMODIFIED DISILOXANE SURFACTANTS
  申请人：Leatherman D. Mark

  公开号：US20070087937A1

  公开（公告）日：2007-04-19

  Compositions comprising an asymmetric disiloxane surfactant composition comprising a silicone composition comprising a silicone having the formula: MM′ where M or M′ comprises an alkylpolyalkyleneoxide bearing substituent selected from the group consisting of: R 13 (C 2 H 4 O) a (C 3 H 6 O) b (C 4 H 8 O) c R 14 and R 12 SiR 5 R 6 (R 13 (C 2 H 4 O) a (C 3 H 6 O) b (C 4 H 8 O) c R 14 ) that exhibit resistance to hydrolysis over a wide pH range.

  本发明涉及一种包含不对称二硅氧烷表面活性剂组合物的组合物，其中包括一种硅氧烷组合物，该硅氧烷组合物具有以下公式：MM'，其中M或M'包括从以下群组中选择的烷基聚烯氧基取代基：R13（C2H4O）a（C3H6O）b（C4H8O）cR14和R12SiR5R6（R13（ ）a（ ）b（ ）cR14），该组合物在广泛的pH范围内表现出对水解的抗性。