1-[(R)-1-(4-Methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-ethanone | 205648-91-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 1-[(R)-1-(4-Methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-ethanone
• CAS: 205648-91-5
• 化学式: C₁₉H₂₅NO₂
• 分子量: 299.413
• InChiKey: YPXQKKBSILHWOE-LJQANCHMSA-N

反应信息

• 作为产物：
  描述：

  (E)-2-acetyl-1,2,3,4,5,6,7,8-octahydro-1-(p-methoxybenzylidene)isoquinoline 在 ((S)-(6,6'-dimethylbiphenyl-2,2'-diyl)bis(diphenylphosphine))Ru(O₂CCF₃)2 、 氢气 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 100.0 ℃ 、6.0 MPa 条件下， 反应 1.0h， 生成 (S)-(+)-N-acetyl-1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline 、 1-[(R)-1-(4-Methoxy-benzyl)-3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-yl]-ethanone
  参考文献：
  名称：

  New efficient methods for the synthesis and in-situ preparation of ruthenium(II) complexes of atropisomeric diphosphines and their application in asymmetric catalytic hydrogenations

  摘要：

  A new synthetically useful method for the synthesis of the diphosphine ruthenium dicarboxylato complexes (P-P)Ru(O2CR)2 (R = CF3 and CH3) is presented, which uses the easily accessible complex (COD)2Ru2(mu-O2CCF3)4 as starting material. This complex as well as (COD)Ru(eta-2-O2CCH3)2 and (COD)2Ru2Cl4(NCCH3) have been shown to be suitable precursor complexes for the in-situ preparation of ruthenium(II) dicarboxylato and dichloro complexes of atropisomeric diphosphines, respectively. The high efficacy of the preformed and in-situ generated ruthenium complexes as precatalysts is demonstrated in asymmetric hydrogenations of allylic alcohols, enamides, and a beta-keto ester.

  DOI：

  10.1016/s0957-4166(00)82157-6