| 1003273-85-5

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• CAS: 1003273-85-5
• 化学式: C₁₃H₂₆OSi
• 分子量: 226.434
• InChiKey: PYFZRSUFIHDCJW-GUFPOKFQSA-N

反应信息

• 作为反应物：
  描述：

  糠醛 、 在 Jacobsen's Cr(III) Schiff base chloride 4 A molecular sieve 作用下， 以 甲醇 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  A Two-Directional Approach to a (−)-Dictyostatin C11−C23 Segment:  Development of a Highly Diastereoselective, Kinetically-Controlled Meerwein−Ponndorf−Verley Reduction

  摘要：

  A three-step synthesis of a precursor to the C11-C23 segment of (-)-dictyostatin is described. The sequence features a sonication-assisted, enantioselective double hetero Diels-Alder (HDA) reaction catalyzed by Jacobsen's Cr(III) Schiff base catalyst, followed by a novel, highly diastereoselective Meerwein-Ponndorf-Verley (MPV) reduction of the hydropyranone subunits under kinetic control to yield the bis(axial alcohol) 4. Generalized studies of both the HDA and MPV methodologies are also described.

  DOI：

  10.1021/ja077336u