| 647859-00-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• CAS: 647859-00-5
• 化学式: C₆₄H₇₅N₈O₁₉P
• 分子量: 1291.32
• InChiKey: JHBOZDHALHQTSA-YXCIBHETSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.97
• 重原子数：
  92.0
• 可旋转键数：
  32.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  310.79
• 氢给体数：
  3.0
• 氢受体数：
  24.0

反应信息

• 作为反应物：
  描述：

  在 diethyldithiocarbonate disulfide 作用下， 生成
  参考文献：
  名称：

  2-Methyl-5-tert-butylthiophenol—An Odorless Deprotecting Reagent Useful in Synthesis of Oligonucleotides and Their Analogs

  摘要：

  A solution of 2-methyl-5-tert-butylthiophenol and triethylamine in acetonitrile efficiently removed the methyl protecting groups from phosphate and phosphorothioate triesters and yielded oligonucleotides of high quality. This inexpensive odorless liquid is not toxic and is a suitable replacement for hazardous thiophenol and other reagents often used for this purpose.graphics.

  DOI：

  10.1081/ncn-120022038
• 作为产物：
  描述：

  3'-O-levulinyl-2'-O-methoxyethyl-N²-isobutyrylguanosine 、 5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-N⁴-benzoyl-5-methylcytidine-3'-O-methyl-N,N'-diisopropylphosphoramidite 在 四氮唑 作用下， 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  2-Methyl-5-tert-butylthiophenol—An Odorless Deprotecting Reagent Useful in Synthesis of Oligonucleotides and Their Analogs

  摘要：

  A solution of 2-methyl-5-tert-butylthiophenol and triethylamine in acetonitrile efficiently removed the methyl protecting groups from phosphate and phosphorothioate triesters and yielded oligonucleotides of high quality. This inexpensive odorless liquid is not toxic and is a suitable replacement for hazardous thiophenol and other reagents often used for this purpose.graphics.

  DOI：

  10.1081/ncn-120022038