Bimiralisib hydrochloride monohydrate | 1820902-73-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: Bimiralisib hydrochloride monohydrate
• 英文别名: 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine;hydrate;hydrochloride
• CAS: 1820902-73-5
• 化学式: C17H23ClF3N7O3
• 分子量: 465.9
• InChiKey: FYHJBNCYIREUGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  13

文献信息

• [EN] NOVEL MANUFACTURING PROCESS FOR TRIAZINE, PYRIMIDINE AND PYRIDINE DERIVATIVES<br/>[FR] NOUVEAU PROCÉDÉ DE FABRICATION DE DÉRIVÉS DE TRIAZINE, PYRIMIDINE ET PYRIDINE
  申请人：UNIV BASEL

  公开号：WO2015162084A1

  公开（公告）日：2015-10-29

  The invention relates to a method of manufacturing triazine, pyrimidine and pyridine derivatives of formula (I), wherein U, V, W and Z are nitrogen or carbon atoms, whereby at least one of U, V and W is nitrogen, and the other substituents are defined as in the specification, by condensing a corresponding halo-triazine, pyrimidine or pyridine in a type of Suzuki coupling with a pyridyl- or pyrimidinyl-borane, wherein the amino function is protected as a formamidine. The invention further relates to suitable intermediates and methods of manufacturing of such intermediates. Furthermore the invention relates to pure 5-(4,6-dimorpholino-1,3,5- triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine in solid form.

  该发明涉及一种制造三嗪、嘧啶和吡啶衍生物的方法，其化学式为(I)，其中U、V、W和Z为氮或碳原子，其中至少一个为氮，其他取代基如说明书中所定义，通过将相应的卤代三嗪、嘧啶或吡啶与吡啶基或嘧啶基硼烷进行铂铃偶联反应，其中氨基功能以甲酰胺基进行保护。该发明还涉及适当的中间体和制造这些中间体的方法。此外，该发明还涉及固态纯的5-(4,6-二吗啉基-1,3,5-三嗪-2-基)-4-(三氟甲基)吡啶-2-胺。
• Manufacturing process for triazine, pyrimidine and pyridine derivatives
  申请人：UNIVERSITAET BASEL

  公开号：US10100031B2

  公开（公告）日：2018-10-16

  The invention relates to a method of manufacturing triazine, pyrimidine and pyridine derivatives of formula (I), wherein U, V, W and Z are nitrogen or carbon atoms, whereby at least one of U, V and W is nitrogen, and the other substituents are defined as in the specification, by condensing a corresponding halo-triazine, pyrimidine or pyridine in a type of Suzuki coupling with a pyridyl- or pyrimidinyl-borane, wherein the amino function is protected as a formamidine. The invention further relates to suitable intermediates and methods of manufacturing of such intermediates. Furthermore the invention relates to pure 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine in solid form.

  本发明涉及一种制造式(I)三嗪、嘧啶和吡啶衍生物的方法，其中 U、V、W 和 Z 为氮原子或碳原子，其中 U、V 和 W 中至少有一个为氮原子，其他取代基定义如说明书所述，制造方法是将相应的卤代三嗪、嘧啶或吡啶与吡啶基或嘧啶基硼烷通过一种类型的铃木偶联进行缩合，其中氨基功能作为甲脒受到保护。本发明还涉及合适的中间体和制造这种中间体的方法。此外，本发明还涉及固体形式的纯 5-(4,6-二吗啉基-1,3,5-三嗪-2-基)-4-(三氟甲基)吡啶-2-胺。
• NOVEL MANUFACTURING PROCESS FOR TRIAZINE, PYRIMIDINE AND PYRIDINE DERIVATIVES
  申请人：Universität Basel

  公开号：EP3134388A1

  公开（公告）日：2017-03-01