N1-azepane-N5-(phenethyl)biguanide hydrochloride | 1422286-68-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环庚烷
• 英文名称: N1-azepane-N5-(phenethyl)biguanide hydrochloride
• 英文别名: N-(N-phenethylcarbamimidoyl)azepane-1-carboximidamide hydrochloride；N1-azepan-N5-(phenethyl)biguanide hydrochloride；N'-[N'-(2-phenylethyl)carbamimidoyl]azepane-1-carboximidamide;hydrochloride
• CAS: 1422286-68-7
• 化学式: C₁₆H₂₅N₅*ClH
• 分子量: 323.869
• InChiKey: VKCHNAJVVQTOHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.58
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  80
• 氢给体数：
  3
• 氢受体数：
  1

文献信息

• Pharmaceutical composition comprising N1-cyclic amine-N5-substituted biguanide derivatives as an ingredient for preventing or treating fibrosis
  申请人：ImmunoMet Therapeutics Inc.

  公开号：US10058558B2

  公开（公告）日：2018-08-28

  The present invention provides a novel use of N1-cyclic amine-N5-substituted biguanide derivatives for preparing a medicine for preventing or treating fibrosis. The N1-cyclic amine-N5-substituted biguanide derivatives according to the present invention are capable of effectively inhibiting fibrosis by effectively suppressing the EMT.

  本发明提供了一种N1-环胺-N5-取代双胍衍生物的新用途，用于制备预防或治疗纤维化的药物。根据本发明的 N1-环胺-N5-取代双胍衍生物能够通过有效抑制 EMT 而有效抑制纤维化。
• PHARMACEUTICAL COMPOSITION COMPRISING N1-CYCLIC AMINE-N5-SUBSTITUTED BIGUANIDE DERIVATIVES AS AN INGREDIENT FOR PREVENTING OR TREATING FIBROSIS
  申请人：IMMUNOMET THERAPEUTICS INC

  公开号：US20160101112A1

  公开（公告）日：2016-04-14

  The present invention provides a novel use of N1-cyclic amine-N5-substituted biguanide derivatives for preparing a medicine for preventing or treating fibrosis. The N1-cyclic amine-N5-substituted biguanide derivatives according to the present invention are capable of effectively inhibiting fibrosis by effectively suppressing the EMT.