2-(Trifluoromethyl)azepane | 383128-99-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环庚烷
• 英文名称: 2-(Trifluoromethyl)azepane
• CAS: 383128-99-2
• 化学式: C₇H₁₂F₃N
• mdl: MFCD02663697
• 分子量: 167.17
• InChiKey: LUTXSAOOFHCLRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• ANILINE DERIVATIVE HAVING ANTI-RNA VIRAL ACTIVITY
  申请人：KinoPharma, Inc.

  公开号：EP2279750A1

  公开（公告）日：2011-02-02

  Viruses, and particularly RNA viruses, have high mutation rates. Hence, antiviral agents that have been developed to date targeting protease or reverse transcriptase of viruses have quickly lost their effectiveness and resistant viruses have emerged. Also, in recent years, viral diseases caused by various new viruses such as SARS, avian influenza, and the hepatitis C have become social menaces. Therefore, the development of a novel antiviral agent that can cope with a virus resistant to an existing drug or a new virus and has a wide range of applications has been demanded. The present invention provides a novel anti-RNA viral agent and a method for use thereof. The present invention further provides an anti-RNA viral agent that is also effective against a new virus or a drug-resistant virus, and a method for use thereof.

  病毒，尤其是 RNA 病毒，变异率很高。因此，迄今为止开发的针对病毒蛋白酶或逆转录酶的抗病毒药物很快就失去了效力，耐药病毒也随之出现。此外，近年来，SARS、禽流感、丙型肝炎等各种新型病毒引起的病毒性疾病已成为社会公害。因此，人们要求开发一种新型的抗病毒药物，以应对对现有药物或新病毒产生耐药性的病毒，并具有广泛的应用前景。本发明提供了一种新型抗 RNA 病毒制剂及其使用方法。本发明进一步提供了一种对新病毒或耐药病毒也有效的抗RNA病毒剂及其使用方法。