3-propionyl-8-oxa-3-aza-bicyclo[3.2.1]octane | 54746-00-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环庚烷
• 英文名称: 3-propionyl-8-oxa-3-aza-bicyclo[3.2.1]octane
• 英文别名: 1-(8-Oxa-3-azabicyclo[3.2.1]octan-3-yl)propan-1-one
• CAS: 54746-00-8
• 化学式: C₉H₁₅NO₂
• 分子量: 169.224
• InChiKey: SEWQRNPCZROSQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] PYRIMIDINE PYRAZOLYL DERIVATIVES<br/>[FR] DÉRIVÉS DE PYRAZOLYL-PYRIMIDINE
  申请人：ARES TRADING SA

  公开号：WO2014008992A1

  公开（公告）日：2014-01-16

  The present invention provides compounds of Formula (I) for the treatment of cancer, rheumatoid arthritis and other diseases (I).

  本发明提供了用于治疗癌症、类风湿性关节炎和其他疾病的式(I)化合物。
• [EN] NAMPT MODULATORS<br/>[FR] MODULATEURS DE NAMPT
  申请人：CYTOKINETICS INC

  公开号：WO2021159015A1

  公开（公告）日：2021-08-12

  Provided are compounds of Formula (II) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, and p are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (II), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (II), or a pharmaceutically acceptable salt thereof.

  提供了公式（II）的化合物或其药用可接受盐，其中R1、R2、R3、R4、R5、R6和p如本文所定义。还提供了包含公式（II）化合物或其药用可接受盐的药用可接受组合物。还提供了使用公式（II）化合物或其药用可接受盐的方法。
• [EN] BENZAMIDE COMPOUNDS AND THEIR USE AS HERBICIDES<br/>[FR] COMPOSÉS DE BENZAMIDE ET LEUR UTILISATION EN TANT QU'HERBICIDES
  申请人：BASF SE

  公开号：WO2019016385A1

  公开（公告）日：2019-01-24

  The present invention relates to benzamide compounds of the formula (I) and the N-oxides and salts thereof and to compositions comprising the same. The variables are as defined in the claims and the description. The invention also relates to the use of the benzamide compounds or of the compositions comprising such compounds for controlling unwanted vegetation. Furthermore, the invention relates to methods of applying such compounds.

  本发明涉及公式（I）的苯甲酰胺化合物及其N-氧化物和盐，以及包含它们的组合物。变量如权利要求和说明书中所定义。本发明还涉及使用苯甲酰胺化合物或包含这种化合物的组合物来控制不良植被。此外，本发明还涉及应用这种化合物的方法。
• [EN] SYNTHESIS OF COMPOUNDS CONTAINING 8-OXA-3-AZABICYCLO (3.2.1)OCTANE RING<br/>[FR] SYNTHÈSE DE COMPOSÉS CONTENANT UN CYCLE 8-OXA-3-AZABICYCLO(3.2.1)OCTANE
  申请人：RHODIA OPERATIONS

  公开号：WO2015109451A1

  公开（公告）日：2015-07-30

  The present invention mainly pertains to catalytic processes for the direct amination of 2, -bis(hydroxymethyl) tetrahydrofuran to obtain compounds containing the 8-oxa-3-azabicyclo (3.2.1) octane ring, in the presence of: a homogenous catalyst which is a complex comprising at least one element selected from the group consisting of Iridium or Ruthenium and at least one donor ligand, or a heterogeneous catalyst comprising at least one Group 8-11 transition metal element and one poor metal element in the p-block of the period table.

  本发明主要涉及催化过程，用于直接对2,-双(羟甲基)四氢呋喃进行胺化反应，以获得含有8-氧杂-3-氮杂双环(3.2.1)辛烷环的化合物，催化剂包括：均相催化剂，其是包含至少一种从铱或钌组成的元素和至少一种给体配体的复合物；或者是一种不均相催化剂，其中包括至少一种8-11族过渡金属元素和一种周期表p区的贫金属元素。
• Aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived PRMT5-inhibitors
  申请人：CTXT PTY LTD

  公开号：US10005792B2

  公开（公告）日：2018-06-26

  A compound of formula (1a), (1b) or (1c) wherein: n is 1 or 2; RN is H or Me; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d (if present) are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4a is selected from OH, —NH2, —C(═O)NH2, and —CH2OH; R4b is either H or Me; R5 is either H or Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl.

  式（1a）、（1b）或（1c）化合物 其中：n 为 1 或 2；RN 为 H 或 Me；R1 可任选为一个或多个卤代或甲基；R2a 和 R2b 独立选自以下组：(i) F；(ii) H；(iii) Me；和 (iv) CH2OH；R2c 和 R2d（如存在）独立选自以下组：(i) F；(ii) H；(iii) Me；和 (iv) CH2OH；R3a 和 R3b 独立选自 H 和 Me；R4a 选自 OH、-NHH 或 Me：(R3a和R3b独立选自H和Me；R4a选自OH、-NH2、-C(═O)NH2和-CH2OH；R4b不是H就是Me；R5不是H就是Me；A是(i)任选取代的苯基；(ii)任选取代的萘基；或(iii)任选取代的C5-12杂芳基。