tert-butyl N-[2-[[2-methyl-2-(methylamino)propanoyl]amino]ethyl]-N-(6-tritylsulfanylhexyl)carbamate | 1422975-29-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: tert-butyl N-[2-[[2-methyl-2-(methylamino)propanoyl]amino]ethyl]-N-(6-tritylsulfanylhexyl)carbamate
• CAS: 1422975-29-8
• 化学式: C₃₇H₅₁N₃O₃S
• 分子量: 617.896
• InChiKey: VDNKNYKZJHZTLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  44
• 可旋转键数：
  18
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  96
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Carrier-Linked Treprostinil Prodrugs
  申请人：Hersel Ulrich

  公开号：US20140296150A1

  公开（公告）日：2014-10-02

  The present invention relates to prodrugs or a pharmaceutically acceptable salt thereof comprising a covalent treprostinil carrier conjugate as well as pharmaceutical composition comprising said compounds. The compounds may be used as medicaments, especially for diseases or disorders which can be treated by treprostinil, such as pulmonary arterial hypertension (PAH).
• Sustained Release Composition of Prostacyclin
  申请人：Sprogøe Kennett

  公开号：US20140303245A1

  公开（公告）日：2014-10-09

  The present invention relates to sustained release compositions of prostacyclin, as well as uses thereof, in particular for the prevention and/or treatment of pulmonary arterial hypertension.
• US9561287B2
  申请人：——

  公开号：US9561287B2

  公开（公告）日：2017-02-07