(1-dipropoxyphosphinooxy-ethyl)-phosphonic acid diethyl ester | 1071709-78-8

• 分子结构分类: 有机化合物 - 有机磷化合物 - 亚磷酸三烷基酯
• 英文名称: (1-dipropoxyphosphinooxy-ethyl)-phosphonic acid diethyl ester
• 英文别名: (1-Dipropoxyphosphinooxy-aethyl)-phosphonsaeure-diaethylester
• CAS: 1071709-78-8
• 化学式: C₁₂H₂₈O₆P₂
• 分子量: 330.298
• InChiKey: FQFAVOIRISPRGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  20.0
• 可旋转键数：
  13.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  63.22
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (1-dipropoxyphosphinooxy-ethyl)-phosphonic acid diethyl ester 在 sulfur 、 苯 作用下， 生成 (1-dipropoxythiophosphoryloxy-ethyl)-phosphonic acid diethyl ester
  参考文献：
  名称：

  Podocyte-Associated Molecules in Puromycin Aminonucleoside Nephrosis of the Rat

  摘要：

  Molecules of central functional significance for the glomerular podocytes are rapidly emerging and have been shown to be distinctly involved in diseases with altered glomerular filtration barrier. Here we used the puromycin aminonucleoside (PA) nephrosis model in the rat to study some key proteins associated with the maintenance of the functional glomerular filtration barrier in vivo. The molecules studied included the filtration slit component nephrin, the hairpin-like membrane protein podocin, the basolateral adhesion molecules beta1 integrin and alpha-dystroglycan, and the cytoskeleton-linking intermediary beta-catenin and the actin-associated alpha-actinin-4. The results showed diminished protein levels of podocin and nephrin in the PA-treated group. beta-catenin showed distinct down-regulation at 3 days of induction, and the control level was reached at 10 days. beta1 integrin was markedly up-regulated during induction. alpha-actinin-4 was not changed at the studied time points. The results show distinct differences in the different domains of podocytes during PA-induced proteinuria.

  DOI：

  10.1097/01.lab.0000017168.26718.16
• 作为产物：
  描述：

  dipropyl phosphorochloridite 、 diethyl 1-hydroxyethylphosphonate 在 三乙胺 作用下， 生成 (1-dipropoxyphosphinooxy-ethyl)-phosphonic acid diethyl ester
  参考文献：
  名称：

  Podocyte-Associated Molecules in Puromycin Aminonucleoside Nephrosis of the Rat

  摘要：

  Molecules of central functional significance for the glomerular podocytes are rapidly emerging and have been shown to be distinctly involved in diseases with altered glomerular filtration barrier. Here we used the puromycin aminonucleoside (PA) nephrosis model in the rat to study some key proteins associated with the maintenance of the functional glomerular filtration barrier in vivo. The molecules studied included the filtration slit component nephrin, the hairpin-like membrane protein podocin, the basolateral adhesion molecules beta1 integrin and alpha-dystroglycan, and the cytoskeleton-linking intermediary beta-catenin and the actin-associated alpha-actinin-4. The results showed diminished protein levels of podocin and nephrin in the PA-treated group. beta-catenin showed distinct down-regulation at 3 days of induction, and the control level was reached at 10 days. beta1 integrin was markedly up-regulated during induction. alpha-actinin-4 was not changed at the studied time points. The results show distinct differences in the different domains of podocytes during PA-induced proteinuria.

  DOI：

  10.1097/01.lab.0000017168.26718.16