2-[N-ethyl-4-[(4-nitrophenyl)diazenyl]anilino]ethyl 1-[2-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]-2-(imidazole-1-carbonyloxy)acetyl]piperidine-4-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 英文名称: 2-[N-ethyl-4-[(4-nitrophenyl)diazenyl]anilino]ethyl 1-[2-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]-2-(imidazole-1-carbonyloxy)acetyl]piperidine-4-carboxylate
• 化学式: C₄₁H₅₃N₄O₆Pol
• 分子量: 783.9
• InChiKey: JAEGYZNIDHTGRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.63
• 重原子数：
  56
• 可旋转键数：
  16
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  174
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  2-[N-ethyl-4-[(4-nitrophenyl)diazenyl]anilino]ethyl 1-[2-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]-2-(imidazole-1-carbonyloxy)acetyl]piperidine-4-carboxylate 在 9-芴甲基-N-琥珀酰亚胺基碳酸酯 、 二乙胺 、 三乙基硅烷 、 三氟乙酸 作用下， 反应 2.0h， 生成
  参考文献：
  名称：

  Nondestructive, Colorimetric Monitoring of Amines and Thiols on a Solid Support

  摘要：

  A new, nondestructive, highly sensitive method for colorimetric monitoring of primary amines, secondary amines, and thiols on a solid support was developed. The resin used in this method is simply regenerated for the repetition of the reaction or an ensuing reaction. By using this new method, several peptides containing secondary amide linkages and C-terminal hydrazide groups were prepared in high purities and yields.

  DOI：

  10.1021/ol901154e
• 作为产物：
  描述：

  N,N'-羰基二咪唑 、 以 二氯甲烷 为溶剂， 反应 3.0h， 以88%的产率得到2-[N-ethyl-4-[(4-nitrophenyl)diazenyl]anilino]ethyl 1-[2-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]-2-(imidazole-1-carbonyloxy)acetyl]piperidine-4-carboxylate
  参考文献：
  名称：

  Nondestructive, Colorimetric Monitoring of Amines and Thiols on a Solid Support

  摘要：

  A new, nondestructive, highly sensitive method for colorimetric monitoring of primary amines, secondary amines, and thiols on a solid support was developed. The resin used in this method is simply regenerated for the repetition of the reaction or an ensuing reaction. By using this new method, several peptides containing secondary amide linkages and C-terminal hydrazide groups were prepared in high purities and yields.

  DOI：

  10.1021/ol901154e