2-[N-ethyl-4-[(4-nitrophenyl)diazenyl]anilino]ethyl 1-[2-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]-2-(4-nitrophenoxy)carbonyloxyacetyl]piperidine-4-carboxylate | 1173994-21-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 英文名称: 2-[N-ethyl-4-[(4-nitrophenyl)diazenyl]anilino]ethyl 1-[2-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]-2-(4-nitrophenoxy)carbonyloxyacetyl]piperidine-4-carboxylate
• CAS: 1173994-21-2
• 化学式: C₄₃H₅₀N₆O₁₁Si
• 分子量: 854.989
• InChiKey: NIMBDCQGBZQEIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.87
• 重原子数：
  61
• 可旋转键数：
  18
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  211
• 氢给体数：
  0
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  、 对硝基苯基氯甲酸酯 在 2,6-二甲基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以60%的产率得到2-[N-ethyl-4-[(4-nitrophenyl)diazenyl]anilino]ethyl 1-[2-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]-2-(4-nitrophenoxy)carbonyloxyacetyl]piperidine-4-carboxylate
  参考文献：
  名称：

  Nondestructive, Colorimetric Monitoring of Amines and Thiols on a Solid Support

  摘要：

  A new, nondestructive, highly sensitive method for colorimetric monitoring of primary amines, secondary amines, and thiols on a solid support was developed. The resin used in this method is simply regenerated for the repetition of the reaction or an ensuing reaction. By using this new method, several peptides containing secondary amide linkages and C-terminal hydrazide groups were prepared in high purities and yields.

  DOI：

  10.1021/ol901154e

文献信息

• Nondestructive, Colorimetric Monitoring of Amines and Thiols on a Solid Support
  作者：Seh-Jin Yang、Xi Zhe Tian、Injae Shin

  DOI：10.1021/ol901154e

  日期：2009.8.6

  A new, nondestructive, highly sensitive method for colorimetric monitoring of primary amines, secondary amines, and thiols on a solid support was developed. The resin used in this method is simply regenerated for the repetition of the reaction or an ensuing reaction. By using this new method, several peptides containing secondary amide linkages and C-terminal hydrazide groups were prepared in high purities and yields.