3,5-dimethoxybenzyllithium | 676468-20-5

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: 3,5-dimethoxybenzyllithium
• CAS: 676468-20-5
• 化学式: C₉H₁₁LiO₂
• 分子量: 158.126
• InChiKey: FHKYZXMILYYJER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.37
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,5-dimethoxybenzyllithium 、 3,5-bis(3-methoxyphenyl)pyridine 1-oxide 以21%的产率得到
  参考文献：
  名称：

  Total synthesis of haouamine A: the indeno-tetrahydropyridine core

  摘要：

  A full account of synthetic efforts toward the indeno-tetrahydropyridine core of haouamine A is presented. initial failed strategies led to the unexpected discovery of a mild abnormal Chichibabin pyridine synthesis and provided knowledge and inspiration for the development of a cascade annulation that has enabled rapid and scalable access to the core in either racemic or enantiopure form. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.05.075

文献信息

• Total synthesis of haouamine A: the indeno-tetrahydropyridine core
  作者：Noah Z. Burns、Mikkel Jessing、Phil S. Baran

  DOI：10.1016/j.tet.2009.05.075

  日期：2009.8

  A full account of synthetic efforts toward the indeno-tetrahydropyridine core of haouamine A is presented. initial failed strategies led to the unexpected discovery of a mild abnormal Chichibabin pyridine synthesis and provided knowledge and inspiration for the development of a cascade annulation that has enabled rapid and scalable access to the core in either racemic or enantiopure form. (C) 2009 Elsevier Ltd. All rights reserved.