2-tert-butyl-4-isopropoxy-6-methoxy-5-pyrimidinecarbaldehyde | 811802-54-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 2-tert-butyl-4-isopropoxy-6-methoxy-5-pyrimidinecarbaldehyde
• 英文别名: 2-Tert-butyl-4-methoxy-6-propan-2-yloxypyrimidine-5-carbaldehyde
• CAS: 811802-54-7
• 化学式: C₁₃H₂₀N₂O₃
• 分子量: 252.313
• InChiKey: NKPSJWLOIJYZLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  61.3
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] PIPERIDYL DERIVATIVES<br/>[FR] DERIVES DE PIPERIDYLE
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2004111000A2

  公开（公告）日：2004-12-23

  A compound of the formula (I): wherein R1, R2, R8, R9 and R10 are each as defined in the description, and -X- is -NH or -O-,Y is (II), (III), (IV), etc., and -Z- is bond or (V) in which R3, R4, R5, R6, R7, and R11 are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism, and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.