4-[1,1-bis-(4-methoxy-phenyl)-1-phenyl-methylthio]-phenylisothiocyanate | 746630-23-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 4-[1,1-bis-(4-methoxy-phenyl)-1-phenyl-methylthio]-phenylisothiocyanate
• 英文别名: 1-[Bis(4-methoxyphenyl)-phenylmethyl]sulfanyl-4-isothiocyanatobenzene
• CAS: 746630-23-9
• 化学式: C₂₈H₂₃NO₂S₂
• 分子量: 469.628
• InChiKey: VQHJMIAMQZUBJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.4
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  88.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] ANTIPROLIFERATIVE 2-(SULFO-PHENYL)-AMINOTHIAZOLE DERIVATIVES<br/>[FR] DERIVES DE 2-(SULFO-PHENYL)-AMINOTHIAZOLE ANTIPROLIFERATIFS
  申请人：PFIZER

  公开号：WO2004072070A1

  公开（公告）日：2004-08-26

  Aminothiazole compounds substituted with sulfur-containing groups are represented by the Formula (I), and their pharmaceutically acceptable salts, prodrugs, active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.

  含有硫基取代基团的氨基噻唑化合物由化学式(I)表示，并描述了它们的药用可接受盐、前药、活性代谢物以及所述代谢物的药用可接受盐。这些药物调节和/或抑制细胞增殖和蛋白激酶活性，可用作治疗恶性肿瘤和其他疾病的药物。
• Antiproliferative 2-(sulfo-phenyl)-aminothiazole derivatives and pharmaceutical compositions, and methods for their use
  申请人：Pfizer, Inc.

  公开号：US20040176431A1

  公开（公告）日：2004-09-09

  Aminothiazole compounds substituted with sulfur-containing groups are represented by the Formula (I), and their pharmaceutically acceptable salts, prodrugs, active metabolites, and pharmaceutically acceptable salts of said metabolites are described. 1 These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.

  含有硫基取代的氨基噻唑化合物的化学式为(I)，其药物可接受的盐、前药、活性代谢物和药物可接受的代谢物的描述如下。这些药物可以调节和/或抑制细胞增殖和蛋白激酶活性，是治疗恶性肿瘤和其他疾病的药物。
• ANTIPROLIFERATIVE 2-(SULFO-PHENYL)-AMINOTHIAZOLE DERIVATIVES
  申请人：PFIZER INC.

  公开号：EP1594866A1

  公开（公告）日：2005-11-16