N-Trityl-butyramide | 20808-86-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: N-Trityl-butyramide
• 英文别名: N-tritylbutanamide
• CAS: 20808-86-0
• 化学式: C₂₃H₂₃NO
• 分子量: 329.442
• InChiKey: GEKDQGOMLRKGCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Cyclic Natriuretic Peptide Constructs
  申请人：Sharma D. Shubh

  公开号：US20070265206A1

  公开（公告）日：2007-11-15

  Cyclic constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group, pharmaceutical compositions including such cyclic constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti-hypertensive, cardiovascular, renal or endocrine effects are desired.

  具有N-端和C-端的循环结构，能够结合到利钠肽受体并包括多种氨基酸残基，至少包括一个公式I的氨基酸替代物：其中，R、R'、Q、Y、W、Z、J、x和n如说明书中所定义的，以及可选地至少一个假体基团，包括这种循环结构的制药组合物，以及治疗充血性心力衰竭或其他需要诱导抗高血压、心血管、肾脏或内分泌效应的情况、综合征或疾病的方法。
• Amide Linkage Cyclic Natriuretic Peptide Constructs
  申请人：Sharma Shubh D.

  公开号：US20100035821A1

  公开（公告）日：2010-02-11

  Cyclic constructs which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z, J, x and n are as defined in the specification, and a cyclic linkage including one or two amide bonds, pharmaceutical compositions including such cyclic constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti-hypertensive, cardiovascular, renal or endocrine effects are desired.

  具有环状结构的构造物，可以与利钠肽受体结合，包括多个氨基酸残基，至少包括一个如下式I所示的氨基酸代用物：其中，R、R'、Q、Y、W、Z、J、x和n的定义如规范中所述，以及包括一个或两个酰胺键的环状连接，包括这种环状构造物的制药组合物，以及治疗充血性心力衰竭或其他需要诱导抗高血压、心血管、肾脏或内分泌效应的情况、综合征或疾病的方法。
• Uses of Natriuretic Peptide Constructs
  申请人：PALATIN TECHNOLOGIES, INC.

  公开号：US20130045928A1

  公开（公告）日：2013-02-21

  Use of constructs which bind to one or more natriuretic peptide receptors and include a plurality of amino acid residues and at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group, for the prophylaxis or treatment of airway diseases, including but not limited to inflammation-related airway diseases, acute asthma or COPD, methods of prophylaxis and treatment of airway diseases and pharmaceutical compositions and formulations for the prophylaxis or treatment of airway diseases.
• Replacement Therapy for Natriuretic Peptide Deficiencies
  申请人：Palatin Technologies, Inc.

  公开号：US20160354443A1

  公开（公告）日：2016-12-08

  Use and methods of use of natriuretic peptide mimetics which bind to and activate natriuretic peptide receptor A in patients with a defect, condition, syndrome, disease or mutation resulting in a functional active ANP 99-126 deficiency, for treatment or prophylaxis of cardiovascular disease, including but not limited to hypertension, acute coronary syndrome, cardiomyopathy, cardiac remodeling, left-ventricular hypertrophy, congestive heart failure, heart failure, high blood pressure and coronary artery disease, including use of mimetics with a plurality of amino acid residues and at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z, J, x and n are as defined in the specification.
• US8580747B2
  申请人：——

  公开号：US8580747B2

  公开（公告）日：2013-11-12