4H-Pyrido<1,2-a>sym-triazin-4-one | 57859-89-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 4H-Pyrido<1,2-a>sym-triazin-4-one
• 英文别名: pyrido[1,2-a][1,3,5]triazin-4-one；Pyrido[1,2-a]-[1,3,5]triazin-4-one；pyrido[1,2-a][1,3,5]triazin-4-one
• CAS: 57859-89-9
• 化学式: C₇H₅N₃O
• 分子量: 147.136
• InChiKey: GIBASIKQQMDVPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-乙氧基-N-(2-吡啶基)甲亚胺 、 三甲基硅基异氰酸酯 以81%的产率得到
  参考文献：
  名称：

  KATO T.; MASUDA S., CHEM. AND PHARM. BULL. , 1975, 23, NO 10, 2251-2256

  摘要：

  DOI：

文献信息

• COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
  申请人：PTC Therapeutics, Inc.

  公开号：US20180105526A1

  公开（公告）日：2018-04-19

  Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.

  本文提供了用于治疗脊髓性肌萎缩症的化合物、其组成物和使用方法。
• METHODS FOR MODULATING THE AMOUNT OF RNA TRANSCRIPTS
  申请人：PTC THERAPEUTICS, INC.

  公开号：US20170000794A1

  公开（公告）日：2017-01-05

  Described herein are methods for modulating the amount of a gene product and compounds for use in such methods. More particularly, described herein are methods for modulating the amount of an RNA transcript or protein product as the result of gene expression and compounds for use in such methods.
• METHODS FOR MODULATING RNA SPLICING
  申请人：PTC Therapeutics, Inc.

  公开号：US20180161456A1

  公开（公告）日：2018-06-14

  In one aspect, described herein is a recognition element for splicing modifier (REMS) that can be recognized by a compound provided herein. In another aspect, described herein are methods for modulating the amount of a product of a gene, wherein a precursor RNA transcript transcribed from the gene contains a REMS, and the methods utilizing a compound described herein. More particularly, described herein are methods for modulating the amount of an RNA transcript or protein product encoded by a gene, wherein a precursor RNA transcript transcribed from the gene comprises a REMS, and the methods utilizing a compound described herein. In another aspect, provided herein are artificial gene constructs comprising a REMS, and uses of those artificial gene constructs to modulate functional protein production. In another aspect, provided herein are methods for altering endogenous genes to comprise a REMS, and the use of a compound described herein to modulate the functional protein produced from such altered endogenous genes.
• US9586955B2
  申请人：——

  公开号：US9586955B2

  公开（公告）日：2017-03-07
• US9879007B2
  申请人：——

  公开号：US9879007B2

  公开（公告）日：2018-01-30