Ethyl 5-n-propyl-1-[2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl-methyl]pyrrole-2-carboxylate | 124806-95-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: Ethyl 5-n-propyl-1-[2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl-methyl]pyrrole-2-carboxylate
• 英文别名: Ethyl 5-n-propyl-1-[2'-(1-triphenylmethyl-tetrazol-5yl)biphenyl-4yl-methyl]pyrrole-2-carboxylate；ethyl 5-propyl-1-[[4-[2-(1-trityltetrazol-5-yl)phenyl]phenyl]methyl]pyrrole-2-carboxylate
• CAS: 124806-95-7
• 化学式: C₄₃H₃₉N₅O₂
• 分子量: 657.815
• InChiKey: DEGYYHVSMFYQOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.7
• 重原子数：
  50
• 可旋转键数：
  13
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  Ethyl 5-(1-propenyl)-1-[2'-(1-triphenylmethyltetrazol-5-yl)biphenyl-4-yl-methyl]pyrrole-2-carboxylate 在 钯 作用下， 以 苯 为溶剂， 反应 4.0h， 以to leave 350 mg of a white solid的产率得到Ethyl 5-n-propyl-1-[2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl-methyl]pyrrole-2-carboxylate
  参考文献：
  名称：

  Substituted 1,2,4-triazole angiotensin II antagonists

  摘要：

  替代吡咯、吡唑和三唑，例如##STR1##及其药学上适宜的盐，可用作降压剂和治疗充血性心力衰竭的药物。

  公开号：

  US05093346A1

文献信息

• Substituted pyrazole angiotensin II antagonists
  申请人：E. I. Du Pont de Nemours and Company

  公开号：US05315013A1

  公开（公告）日：1994-05-24

  Substituted pyrazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.

  取代吡唑类化合物如##STR1##及其药用盐可用作降压药物和治疗充血性心力衰竭的药物。
• Treatment of hypertension with 1,2,4-angiotensin II antagonists
  申请人：E. I. Du Pont de Nemours and Company

  公开号：US05015651A1

  公开（公告）日：1991-05-14

  Substituted pyrroles, pyrazoles and traizoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.

  取代基嘧啶、吡唑和三唑类化合物，如##STR1##及其药用盐，可用作降压药物和治疗充血性心力衰竭的药物。
• Substituted 1,2,3 triazole angiotensin II antagonists
  申请人：E. I. Du Pont de Nemours and Company

  公开号：US05189048A1

  公开（公告）日：1993-02-23

  This invention includes substituted pyrroles, pyrazoles and triazoles, processes for their preparation, pharmaceutical compositions containing them, and their use as antihypertensive agents, and as a treatment for congestive heart failure in mammals. The heterocyclic compounds of the invention have the structural formula (I) ##STR1## or pharmaceutically suitable salts thereof.

  本发明涉及取代的吡咯、吡唑和三唑，它们的制备方法，含有它们的药物组合物，以及它们作为抗高血压剂和哺乳动物充血性心力衰竭的治疗方法。 本发明的杂环化合物具有结构式（I）##STR1##或其药学上适宜的盐。
• Substituted pyrrole angiotensin II antagonists
  申请人：E. I. Du Pont de Nemours and Company

  公开号：US05043349A1

  公开（公告）日：1991-08-27

  Substituted pyrroles, pyrazoles and triazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.

  取代的吡咯、吡唑和三唑，如##STR1##及其药学上适合的盐，可用作降压剂和治疗充血性心力衰竭的药物。
• Substituted 1,2,3-triazole angiotensin II antagonists
  申请人：E. I. du Pont de Nemours and Company

  公开号：US05081127A1

  公开（公告）日：1992-01-14

  Substituted pyrroles, pyrazoles and triazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.

  取代的吡咯、吡唑和三唑，例如##STR1##及其药学上适宜的盐可用作降压药物和治疗充血性心力衰竭的药物。